Effect of phosphodiesterase inhibitors on nitric oxide production by glial cells

Tohoku Journal of Experimental Medicine

Volumn 196, Issue 3, 2002, Pages 167-177

  Yoshikawa, Minka ^a,c   Suzumura, Akio ^b   Ito, Atsushi ^a   Tamaru, Tsukasa ^a   Takayanagi, Tetsuya ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c Nara Prefectural Rihabilitation Center   (Japan)

Author keywords

Astrocytemicroglia; Nitric oxide; Phosphodiesterase inhibitor; Tumor necrosis factor

Indexed keywords

CILOSTAZOL; CYCLIC AMP; DIPYRIDAMOLE; IBUDILAST; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAPAVERINE; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA; VINPOCETINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NITRITE; NOS2 PROTEIN, MOUSE; NOS2A PROTEIN, HUMAN; RECOMBINANT PROTEIN; NOS2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; GLIA CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEWBORN; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; GLIA; HUMAN; METABOLISM; DRUG EFFECTS;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; NEUROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PHOSPHODIESTERASE INHIBITORS; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035991431     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.196.167     Document Type: Article

References (29)

1. Nitric oxide synthesis in rat peritoneal macrophage is induced by IgE/DNP complexes and cyclic AMP analogues
2. Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors
3. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
4. Tumor necrosis factor-α potentiates glutamate neurotoxicity in human fetal brain cell cultures
5. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice
6. Microglia involvement in the acquired immunodeficiency syndrome (AIDS)
7. Analysis of nitrate, nitrite, and (15 N) nitrite in biological fluids
8. Differential regulation of cytokine-induced major histocompatibility complex class II expression and nitric oxide release in rat microglia and astrocytes by effectors of tyrosine kinase, protein kinase C, and cAMP
9. Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation
10. Preventive but not therapeutic application of Rolipram ameliorates experimental autoimmune encephalomyelitis in Lewis rats
11. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate
12. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
13. Pentoxifylline inhibits experimental allergic encephalomyelitis
14. Effect of the phosphodiesterase III inhibitor amrinone on cytokine and nitric oxide production in immunostimulated J774.1 macrophages
15. Inhibition of inducible nitric oxide synthase expression by endothelin in rat glial cells prepared from the neonatal rat brain
16. Release of tumor necrosis factor-α from macrophages
17. Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
18. Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors
19. Expression of nitric-oxide synthase in rat kupffer cells is regulated by cAMP
20. Nitric Oxide mediate neuronatal injury in multiple sclerosis
21. The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis
22. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline
23. The isolation and long-term culture of oligodendrocytes from newborn mouse brain
24. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain; induction of Ia antigen expression by gamma-interferon
25. Induction of glial cell MHC antigen expression in neurotropic corona virus infection; characterization of the H-2 inducing soluble factor elaborated by infected brain cells
26. Effects of combined therapy of phosphodiesterase inhibitors on experimental allergic encephalomyelitis
27. Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis
28. Effects of phosphodiesterase inhibitors on cytokine production by microglia
29. Oxygen free radicals and neurodegeneration in Parkinson's disease: A role of nitric oxide