Renal concentrating and diluting function in deficiency of specific aquaporin genes

Experimental Nephrology

Volumn 10, Issue 4, 2002, Pages 235-240

  Verkman, Alan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aquaporins; Transgenic mouse; Urinary concentrating mechanism; Water transport

Indexed keywords

AQUAPORIN; ISOPROTEIN;

GENE DELETION; GENE FUNCTION; GENE TARGETING; HYPOTHESIS; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; MAMMAL; MEDICAL RESEARCH; NONHUMAN; OSMOSIS; PERITONEAL DIALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; TRANSGENIC MOUSE; WATER FLOW; ANIMAL; GENETICS; KIDNEY; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW;

ANIMALS; AQUAPORINS; KIDNEY; KIDNEY CONCENTRATING ABILITY; MICE; MICE, TRANSGENIC;

EID: 0035991134     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063697     Document Type: Short Survey

References (15)

1. Early neonatal mortality in a transgenic AQP2 knock-in model of nephrogenic diabetes insipidus
2. Nephrogenic diabetes insipidus in mice deficient in aquaporin-3 water channels
3. Generation and phenotype of a transgenic knock-out mouse lacking the mercurial-insensitive water channel aquaporin-4
4. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
5. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
6. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
7. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
8. Luminal hypotonicity in proximal tubules of aquaporin-1 knockout mice
9. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice
10. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta
11. Four-fold reduction in water permeability in inner medullary collecting duct of aquaporin-4 knockout mice
12. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery
13. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4
14. Reduced water permeability of the peritoneal barrier in aquaporin-1 knockout mice
15. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice