Effect of stimulators such as GLP-1, PACAP, and nicotinamide on glucose-stimulated insulin secretion from porcine pancreatic endocrine cells in long-term culture

Pancreas

Volumn 25, Issue 1, 2002, Pages 86-93

  Sato, Ayako ^a   Wang, Pi Chao ^a   Ohgawara, Hisako ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

GLP 1; Long term culture; Monolayer culture; Nicotinamide; PACAP; Porcine pancreatic endocrine cell (PE cells)

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INSULIN; NICOTINAMIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; GLUCAGON; GLUCOSE; NEUROPEPTIDE; PEPTIDE FRAGMENT; PROTEIN PRECURSOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; ENDOCRINE CELL; IMMUNOCYTOCHEMISTRY; INSULIN RELEASE; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; SWINE; ANIMAL; CELL SEPARATION; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; INSTRUMENTATION; PANCREAS ISLET; SECRETION;

ANIMAL; CELL ADHESION; CELL SEPARATION; CELLS, CULTURED; CULTURE MEDIA; GLUCAGON; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; NEUROPEPTIDES; NEUROTRANSMITTERS; NIACINAMIDE; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; SUPPORT, NON-U.S. GOV'T; SWINE; ANIMALS; GLUCAGON-LIKE PEPTIDE 1; NEUROTRANSMITTER AGENTS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE;

EID: 0035990277     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200207000-00019     Document Type: Article

References (19)

1. Prolongation of islet xenograft survival without continuous immunosuppression
2. Islet transplantation with immunoisolation
3. Significance of the peri-Insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man
4. Porcine islet isolation, cellular composition and secretory response
5. Massive isolation, morphological and functional characterization, and xenotransplantation of bovine pancreatic islet
6. A method for massive separation of highly purified adult porcine islet of Langerhans
7. Insulin release in response to glucose from isolated mouse, rat, porcine, bovine, and human pancreatic islets
8. Establishment of monolayer culture of pig pancreatic endocrine cells by use of nicotinamide
9. Preparation of adult pig pancreatic cell: Comparative study of methods with or without proteolytic enzymes
10. Exon duplication and divergence in the human preproglucagon gene
11. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
12. Signal transduction of PACAP and GLP-1 in pancreatic β cells
13. Glucagon-kike peptide 1 and exendin-4 convert pancreatic AR42J cell into glucagon-and insulin-producing cells
14. Nicotinamide is a potent inducer of endocrine differentiation in cultured human feral pancreatic cells
15. Insulinotropic glucagon-Like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
16. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
17. Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in chines hamster ovary cells
18. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
19. Polyamine requirements in nicotinamidestimulated β-cell differentiation in fetal porcine islet-like cell clusters