Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones

Molecular Biology and Evolution

Volumn 19, Issue 7, 2002, Pages 1083-1092

  Yi, Soojin ^a   Bernat, Bryan ^a   Pál, Gábor ^a   Kossiakoff, Anthony ^a   Li, Wen Hsiung ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Growth hormone; Growth hormone receptor; Species specificity; Surface plasmon resonance

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE; ARGININE; DNA;

AFFINITY CHROMATOGRAPHY; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; EVOLUTION; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENETIC SELECTION; HORMONE RECEPTOR INTERACTION; MUTAGENESIS; NONHUMAN; PLASMID; PRIMATE; SEQUENCE ANALYSIS; SPECIES DIFFERENCE; SQUIRREL MONKEY; SURFACE PLASMON RESONANCE; ANIMAL; BINDING SITE; CEBIDAE; CHEMISTRY; DNA SEQUENCE; GENETIC VARIABILITY; GENETICS; HUMAN; MOLECULAR EVOLUTION; MUTATION; PROTEIN BINDING; RAT;

EUTHERIA; MAMMALIA; PLATYRRHINI; PRIMATES; SAIMIRI; SCIURIDAE;

ANIMALS; ARGININE; BINDING SITES; DNA; EVOLUTION, MOLECULAR; GROWTH HORMONE; HUMANS; MUTATION; PROTEIN BINDING; RATS; RECEPTORS, SOMATOTROPIN; SAIMIRI; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; SPECIES SPECIFICITY; VARIATION (GENETICS);

EID: 0035986872     PISSN: 07374038     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.molbev.a004166     Document Type: Article

References (23)

1. Aspartate 171 is the major primate-specific determinant of human growth hormone
2. Growth hormone and insulin binding to human liver
3. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity
4. A hot spot of binding energy in a hormone-receptor interface
5. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis
6. High-resolution epitope mapping of hGH-receptor interaction by alanine-scanning mutagenesis
7. Rational design of receptor-specific variants of human growth hormone
8. Comparison of a structural and a functional epitope
9. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
10. Real-time DNA binding measurements of the ETS1 recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms
11. The human growth hormone receptor
12. Toward a phylogenetic classification of primates based on DNA evidence complemented by fossil evidence
13. Structure of the growth hormone-receptor complex and mechanism of receptor signaling
14. Rapid and efficient site-specific mutagenesis without phenotypic selection
15. Episodic evolution of growth hormone in primates and emergence of the species specificity of human growth hormone receptor
16. The species specificity of growth hormone requires the cooperative interaction of two motifs
17. The X-ray structure of a growth hormone-prolactin receptor complex
18. A single arginine residue determines species specificity of the human growth hormone receptor
19. Variable evolutionary rates in the molecular evolution of mammalian growth hormones
20. The molecular evolution of vertebrate growth hormone: A pattern of near-stasis interrupted by sustained bursts of rapid change
21. Molecular evolution of GH in primates: Characterization of the GH genes from slow loris and marmoset defines an episode of rapid evolutionary change
22. Structural and functional basis for hormone binding and receptor oligomerization