Interstitial deletions at the long arm of chromosome 13 may be as common as monosomies in multiple myeloma. A genotypic study

Haematologica

Volumn 87, Issue 8, 2002, Pages 828-835

  Nomdedéu, Josep F ^a   Lasa, Adriana ^a   Úbeda, Josep ^a   Saglio, Giuseppe ^a   Bellido, Mar ^a   Casas, Sílvia ^a   Carnicer, Maria J ^a   Aventín, Anna ^a   Sureda, Anna ^a   Sierra, Jorge ^a   Baiget, Montserrat ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Chromosome 13; Genetics; Loss of heterozygosity; Multiple myeloma

Indexed keywords

CELL DNA; DNA; MICROSATELLITE DNA;

ADULT; AGED; ARTICLE; BONE MARROW; CARCINOGENESIS; CHROMOSOME 13Q; CHROMOSOME DELETION 13; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DEVICE; ELECTROPHORESIS; FEMALE; FLOW CYTOMETRY; GENE AMPLIFICATION; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; MALE; MONOSOMY; MULTIPLE MYELOMA; PLASMA CELL; BRAZIL; CHROMOSOME 13; CHROMOSOME DELETION; CHROMOSOME MAP; COMPARATIVE STUDY; GENETIC MARKER; GENETICS; IMMUNOPHENOTYPING; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ADULT; AGED; BRAZIL; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 13; COMPARATIVE STUDY; DNA, NEOPLASM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENETIC MARKERS; GENOTYPE; HUMAN; IMMUNOPHENOTYPING; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGE; MONOSOMY; MULTIPLE MYELOMA; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION; SUPPORT, NON-U.S. GOV'T; HUMANS; MIDDLE AGED;

EID: 0035986761     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Multiple myeloma: Evolving genetic events and host interactions
2. Chromosome translocations in multiple myeloma
3. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
4. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
5. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
6. Incidence of chromosome numerical changes in multiple myeloma: Fluorescence in situ hybridization analysis using 15 chromosome-specific probes
7. Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma
8. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
9. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
10. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
11. Multiple myeloma: Almost all patients are cytogenetically abnormal
12. Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization
13. Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy
14. Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13
15. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma
16. Deletion of 13q14 remains an independent adverse prognostic variable uin multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization
17. The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance
18. Among numerous DNA copy number changes, losses of chromosome 13 are highly recurrent in plasmacytoma
19. Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization
20. Biological and prognostic significance of Interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (δ13) in multiple myeloma: An Eastern Cooperative Oncology Group Study
21. Allelic loss determination in chronic lymphocytic leukemia by immunomagnetic bead sorting and microsatellite marker analysis
22. Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation
23. The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells
24. Comparative genomic hybridization, loss of heterozygosity and DNA sequence analysis of single cells
25. Whole genome amplification using a degenerate oligonucleotide primer allows hundreds of genotypes to be performed on less than one nanogram of genomic DNA
26. Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia
27. Frequent allelic loss of the RB, D13S319 and D13S25 locus in myeloid malignancies with deletion/translocation at 13q14 of chromosome 13, but not in lymphoid malignancies
28. Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia
29. Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia
30. Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
31. Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma