Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects

Diabetes and Metabolism

Volumn 28, Issue 3, 2002, Pages 209-215

  Reis, A F ^a   Hani, E H ^a   Beressi, N ^a   Robert, J J ^a   Bresson, J L ^a   Froguel, P ^a   Velho, G ^a  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

Author keywords

Glucose clearance; Glucose infusion; Insulin secretion; Insulin sensitivity; Sulfonylurea receptor

Indexed keywords

C PEPTIDE; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 1; UNCLASSIFIED DRUG; ABC TRANSPORTER; DRUG RECEPTOR; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL;

ADULT; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; EXON; FEMALE; GENE; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; RELATIVE; AMINO ACID SUBSTITUTION; BLOOD; FAMILY; GENETICS; GLUCOSE BLOOD LEVEL; KINETICS; METABOLISM; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; REFERENCE VALUE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SECRETION; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; EXONS; FAMILY; GENOTYPE; HUMAN; INSULIN; KINETICS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS; RECEPTORS, DRUG; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; VARIATION (GENETICS); ATP-BINDING CASSETTE TRANSPORTERS; DIABETES MELLITUS, TYPE 2; HUMANS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 0035986343     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. ATP-sensitive K + channels and insulin secretion: Their role in health and disease
2. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in caucasians
3. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
4. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene
5. Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM
6. Variants in the sulfonylurea receptor gene: Association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians
7. Sulfonylurea receptor-1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
8. Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians
9. Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations
10. Prehepatic insulin production in man: Kinatic analysis using peripheral connecting peptide behavior
11. A computer program to reconstruct insulin secretion
12. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
13. Effects of plasma glucose concentration on glucose utilization and glucose clearance in normal man
14. Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
15. Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus
16. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: The sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1 alpha genes
17. Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-gene variant and hyperin-sulinemia
18. Sulfonylurea receptor -1 (SUR1): Genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus
19. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene
20. Identification of microsatellite markers near the human genes encoding the beta-cell ATP-Sensitive k + channel and linkage studies with NIDDM in Japanese