Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity

Japanese Journal of Pharmacology

Volumn 88, Issue 4, 2002, Pages 451-458

  Mitani, Hironobu ^a   Takimoto, Misato ^a   Kimura, Masaaki ^a  

^a NOVARTIS PHARMA K K   (Japan)

Author keywords

Aging; Diabetes; Dipeptidyl peptidase IV; Fischer 344 rat; Glucose tolerance

Indexed keywords

1 [2 [(5 CYANOPYRIDIN 2 YL)AMINO]ETHYLAMINO]ACETYL 2 CYANOPYRROLIDINE; 6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; GLUCOSE; INCRETIN; INSULIN; PROTEIN; UNCLASSIFIED DRUG; LIPID; NITRILE; NVP-DPP728; PROTEINASE INHIBITOR; PYRROLIDINE DERIVATIVE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANNULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; INSULIN RESPONSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; RAT STRAIN; ANIMAL; BLOOD; COMPARATIVE STUDY; ENZYMOLOGY; FISCHER 344 RAT; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; METABOLISM; ORAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, ORAL; AGING; ANIMALS; ANTIGENS, CD26; BLOOD GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN; LIPIDS; NITRILES; PROTEASE INHIBITORS; PYRROLIDINES; RATS; RATS, INBRED F344; RATS, WISTAR;

EID: 0035985285     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.451     Document Type: Article

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