The insulin-mediated vascular and blood pressure responses are suppressed in CGRP-deficient normal and diabetic rats

Diabetes/Metabolism Research and Reviews

Volumn 18, Issue 3, 2002, Pages 238-244

  Salem, Nahla ^a   Dunbar, Joseph C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Capsaicin; CGRP; Diabetic; Insulin; Mean arterial pressure

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CHLORALOSE; GLUCOSE; INSULIN; URETHAN; ANTIDIABETIC AGENT;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; BLOOD VESSEL INNERVATION; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; HEART RATE; HEMODYNAMICS; ILIAC ARTERY; INSULIN INFUSION; INSULIN RESPONSE; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; RENAL ARTERY; STREPTOZOCIN DIABETES; SUPERIOR MESENTERIC ARTERY; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; BLOOD FLOW VELOCITY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMAL; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; DIABETES MELLITUS, EXPERIMENTAL; HEART RATE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; RATS; RATS, WISTAR; ANIMALS;

EID: 0035985244     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.293     Document Type: Article

References (31)

1. The effect of ventral medial hypothalamic lesion on the insulin-induced hypotensive response in normal rats
2. The effect of insulin-induced hypoglycemia, 2-deoxyglucose-induced glucopenia and hyperglycemia on cardiovascular tone in normal and diabetic rats
3. Regional blood flow dynamics in response to insulin and IGF-1 in diabetic animals
4. Beta adrenergic-mediated vasodilator response to insulin in the human forearm
5. Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans
6. Dilation of isolated skeletal muscle arterial by insulin is endothelium dependent and nitric oxide mediated
7. 2+ concentration
8. Mechanisms mediating the insulin-induced hypotension in rats: A role for nitric oxide and autonomic mediators
9. Insulin signaling in the arterial wall
10. Human insulin-mediated enhancement of vascular beta-adrenergic responsiveness
11. Vascular actions of insulin in obesity
12. The effect of general and selective β-adrenergic antagonist on the insulin-induced cardio and selected vascular responses in rats
13. Calcitonin gene-related peptide and its receptors: Molecular genetics, physiology, pathophysiology and therapeutic potential
14. Neurochemical distinction between skeletal muscle vasodilator neurons and pelvic vasodilator neurons in guinea pigs
15. Neurogenic vasodilation in rabbit basilar isolated artery: Involvement of calcitonin gene related peptide
16. Nerve growth factor (NGF) restores depletion of calcitonin gene-related peptide and substance P in sensory neurons from diabetic mice in vitro
17. Mechanism by which calcitonin gene-related peptide antagonize insulin action in vivo
18. Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knock-out mice
19. Renal microvascular actions of calcitonin gene-related peptide
20. Depletion of substance P and calcitonin gene related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition
21. Vascular dilatatory response to sodium nitroprusside (SNP) and α-adrenergic antagonism in female and male normal and diabetic rats
22. Neonatal capsaicin treatment does not prevent splanchnic vasodilatation in portal-hypertensive rats
23. Pattern of innervation of sympathetic vascular neurons by peptide-containing primary sensory fibers
24. The effect of neonatal capsaicin on plasma levels and tissue content of CGRP
25. Neonatal deafferatation of capsaicin-sensitive nerves increases in vivo insulin sensitivity in conscious adult rats
26. Involvement of calcitonin gene related peptide (CGRP) receptors in insulin-induced vasodilatation in mesenteric resistant blood vessels of rats
27. Long-term sensory denervation by neonatal capsaicin treatment augments sympathetic neurotransmission in rat mesenteric arteries by increasing levels of norepinephrine and selectively enhancing post-junctional actions
28. Calcitonin gene-related peptide causes long-term inhibition of contraction in rat thoracic aorta through a nitric oxide-dependent pathway
29. Insulin modulation of beta-adrenergic vasodilator pathway in human forearm
30. The effect of long-term streptozotocin-induced diabetes on contractile and relaxation responses of coronary arteries: Selective attenuation of CGRP-induced relaxation
31. To co-existence of insulin-mediated decreased mean arterial pressure and increased sympathetic nerve activity is not mediated by the baroreceptors reflex or hypoglycemia