Mechanisms mediating insulin-induced hypotension in rats: A role for nitric oxide and autonomic mediators

Acta Diabetologica

Volumn 33, Issue 4, 1996, Pages 263-268

  Dunbar, J C ^a   O'Leary, D S ^a   Wang, G ^a   Wright Richey, J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic antagonists; Atenolol; Atropine; Cholinergic antagonist; Ganglionic blockers; Hexamethonium; Insulin induced hypotension; L NAME; Nitric oxide; Prazosin

Indexed keywords

ADRENALIN; ATENOLOL; ATROPINE; CHOLINERGIC RECEPTOR; GLUCOSE; HEXAMETHONIUM; INSULIN; NITRIC OXIDE; NORADRENALIN; PRAZOSIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GANGLION BLOCK; GLUCOSE BLOOD LEVEL; HEART RATE; INDUCED HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ATENOLOL; ATROPINE; AUTONOMIC NERVOUS SYSTEM; BLOOD GLUCOSE; BLOOD PRESSURE; COHORT STUDIES; ENZYME INHIBITORS; HEART RATE; HEXAMETHONIUM; HYPOGLYCEMIC AGENTS; HYPOTENSION; INSULIN; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PRAZOSIN; RATS; RATS, WISTAR;

EID: 0030447904     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00571561     Document Type: Article

References (31)

1. Liang C-S, Doherty JW, Faillace R, Maekawa K, Arnold S, Gauras H et al, Insulin infusion in conscious dogs. Effect on systemic and coronary hemodynamics. regional blood flows and plasma catecholamines. J Clin Invest 69:1321-1336, 1982
2. Baron AD, Brechtel G, Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol 265: E61-E67, 1993
3. Laakso M, Edelman SU, Brechtel G, Baron AD, Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest 85:1844-1852, 1990
4. Baron AD, Brechtel-Hook G, Johnson A, Hardin D, Skeletal muscle blood flow: a possible link between insulin resistance and blood pressure. Hypertension 21:129-135, 1993
5. Wright-Richey J, Schultz-Klarr S, Dunbar JC, The effect of ventral medial hypothalamic lesion on the insulin-induced hypotensive response in normal rats. Acta Diabetol 31:91-97, 1994
6. Schultz-Klarr S, Wright-Richey J, Dunbar JC, Effect of insulin-induced hypoglycemia, 2-deoxyglucose-induced glucose cytopenia and hyperglycemia on cardiovascular tone in normal and diabetic rats. JAAMP 5:152-158, 1994
7. Schultz-Klarr S, Wright-Richey J, Dunbar JC, Plasma glucose, insulin, and cardiovascular responses after intravenous and intracerebroventricular injections of insulin, 2-deoxyglucose and glucose in rats. Diab Res Clin Pract 26:81-89, 1994
8. Alexander WD, Oake RJ, The effect of insulin on vascular reactivity to norepinephrine. Diabetes 26:611-614, 1977
9. MacLeod KM, The effect of insulin treatment on changes in vascular reactivity in chronic experimental diabetes. Diabetes 34:1160-1167, 1985
10. Anderson EA, Huffman RP, Balon TW, Sinkey CA, Mark AL, Hypennsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87:2246-2252, 1991
11. Rowe JW, Young JB, Minoker KL, Stevens AL, Pollotta J, Landsberg L, Effect of insulin and glucose infusion on sympathetic nervous system activity in normal man. Diabetes 30:219-225, 1981
12. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD, Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94:1172-1179, 1994
13. Kahn AM, Seidel CL, Allen JC, O'Neil RG, Shelat H, Song T, Insulin reduces contractions and intracellular calcium concentration in vascular smooth muscle. Hypertension 22:735-742, 1993
14. Nishimura M, Takahashi H, Motsusawa M, Ikegaki I, Nakanishi T, Yoshimura M, The effect of insulin and insulin-like materials in the brain on central cardiovascular regulation: with special reference to the central effect of sodium chloride. J Hypertens 9:509-517, 1991
15. Kuo SW, Hsieh JH, Wu WC, Horng HT, Shian LR, Chai CY, Effect of insulin on the cardiovascular integrating mechanism of the brain stem in cats. Am J Physiol 265:E609-E616, 1993
16. Furchgott RF, Vanhoutte PM, Endothelium-derived relaxing and contracting factors. FASEB J 3:2007-2018, 1989
17. Yang BC, Nichols WW, Mehta JL, Cardiac effects of acetylcholine in rat hearts: role of endothelium-derived relaxing factor and prostaglandins. Am J Physiol 264:H1388-H1393, 1993
18. Hickner RC, Ungerstedt U, Henricksson J, Regulation of skeletal muscle blood flow during acute insulin-induced hypoglycemia in the rat. Diabetes 43:1340-1344, 1994
19. Anderson EA, Mark AL, The vasodilator action of insulin. Implication for the insulin hypothesis of hypertension. Hypertension 21:136-141, 1993
20. Baron AD, Hemodynamic action of insulin. Am J Physiol 267: E187-E202, 1994
21. Porcellati F, Fanelli C, Battini P, Epifano L, Rambotti AM, Lalli C et al. Mechanism of arterial hypotension after therapeutic doses of subcutaneous insulin in diabetic autonomic neuropathy. Diabetes 42:1055-1064, 1993
22. Page MM, Watkins PJ, Provocation of postural hypotension by insulin in diabetic autonomic neuropathy. Diabetes 25:90-95, 1976
23. Reavens CM, Ho H, Sugar-induced hypertension in Sprague-Dawley rats. Am J Hypertens 4:610-614, 1991
24. Lansberg L, Diet, obesity and hypertension an hypothesis involving insulin, the sympathetic nervous system and adaptive thermogenesis. Q J Med 236:1081-1090, 1986
25. Mahler RJ, Diabetes and hypertension. Horm Metab Res 22: 599-607, 1990
26. Kawashima H, Igarashi T, N:akajima Y, Akiyama Y, Usuki K, Ohtake S, Chronic hypertension induced by streptozotocin in rats. Naunyn Schmiedebergs Arch Pharmacol 305:123-126, 1978
27. Fisher BM, Gillen G, Hepburn DA, Dorgie HJ, Frier BM, Cardiac responses to acute insulin-induced hypoglycemia in humans. Am J Physiol 258:H1775-H1779, 1990
28. Creager MA, Liang C-S, Coffman JD, Beta adrenergic-mediated vascular response to insulin in the human forearm. J Pharmacol Exp Therap 235:709-714, 1985
29. Edwards JG, Tipton CM, Influences of exogenous insulin on arterial blood pressure measurements of the rat. J Appl Physiol 67: 2335-2342, 1989
30. Kalsner S. Cholinergic constriction in the general circulation and its role in coronary artery spasm. Circ Res 65:237-257, 1989
31. Valiquette M, Parent S, Loisel TP, Bouvier M, Mutation of tyrosine-141 inhibits insulin promoted tyrosine phosphorylation and increased responsiveness of the human beta-2 adreneraic receptor. EMBO J 14:5542-5549, 1995