Design of inhibitors for human tissue kallikrein using non-natural aromatic and basic amino acids

Biological Chemistry

Volumn 383, Issue 5, 2002, Pages 853-857

  Pimenta, Daniel C ^a   Melo, Robson L ^a   Caliendo, Giuseppe ^a   Santagada, Vincenzo ^a   Fiorino, Ferdinando ^a   Severino, Beatrice ^a   de Nucci, Gilberto ^a   Juliano, Luiz ^a   Juliano, Maria A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Human tissue kallikrein; Inhibitors; Kallikrein; Non natural amino acids; Synthetic peptides

Indexed keywords

ACETIC ACID DERIVATIVE; ALANINE DERIVATIVE; AMINE; AMINO ACID DERIVATIVE; ARGININE; AROMATIC AMINO ACID; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; PEPTIDE DERIVATIVE; PHENYL GROUP; PHENYLALANINE; PHENYLALANINE DERIVATIVE; PHENYLGLYCINE; SERINE; TISSUE KALLIKREIN INHIBITOR; UNCLASSIFIED DRUG; AMINO ACID; TISSUE KALLIKREIN;

AMINO ACID SUBSTITUTION; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HYDROPHOBICITY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS, AROMATIC; AMINO ACIDS, BASIC; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMAN; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TISSUE KALLIKREINS; HUMANS;

EID: 0035985074     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.091     Document Type: Article

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