Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells

Anticancer Research

Volumn 22, Issue 3, 2002, Pages 1491-1496

  Jiang, Jiahua ^a   Ghosh, Pradip K ^a   Kulp, Samuel K ^a   Sugimoto, Yasuro ^a   Liu, Suling ^a   Czekajewski, Jan ^a   Chang, Hsiang Lin ^a   Lin, Young C ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

CO2 production; Gossypol; O2 consumption; Prostate cancer; Succinic dehydrogenase

Indexed keywords

CARBON DIOXIDE; GOSSYPOL; OXYGEN; SUCCINATE DEHYDROGENASE; DNA; GROWTH INHIBITOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROSTATE CANCER; RAT; RESPIROMETER; TUMOR CELL LINE; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; PROSTATE TUMOR;

CARBON DIOXIDE; DNA, NEOPLASM; GOSSYPOL; GROWTH INHIBITORS; HUMANS; MALE; MITOCHONDRIA; OXYGEN; OXYGEN CONSUMPTION; PROSTATIC NEOPLASMS; SUCCINATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

EID: 0035984233     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Lactic dehydrogenase isozymes P31 magnetic response spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123
2. Glycolysis as primary energy source in tumor cell chemotaxis
3. Antimitochondrial drugs in cancer chemotherapy: Preliminary communication
4. Effect of gossypol on immature male rats
5. Effect of gossypol on the fertility of male rats
6. Inhibitory action of gossypol on rat prostate
7. 1 transfected human fibrosarcoma cells
8. Inhibition of human prostate cancer cell growth by gossypol is associated with stimulation of transforming growth factor-β
9. Antiproliferative and antimetastatic effect of gossypol on Dunning prostatic cell-bearing Copenhagen rats
10. The effects of gossypol on the invasiveness of MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats
11. Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle
12. The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor β1 production
13. Induction of p53 by gossypol in MCF-7 cells
14. Interaction of gossypol with sperm macromolecules and enzymes
15. Enzyme interaction and inhibition by gossypol
16. In vitro inhibition by gossypol of oxidoreductase from human tissues
17. Effect of gossypol on spermatozoal lactate dehydrogenase-x (LDH-X) in male rats
18. Primary mitochondrial activity of gossypol in yeast and mammalian
19. Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantimors
20. Adaptability of the oxidative capacity of motoneurons
21. Impaired succinic dehydrogenase activity of rat Purkinje cell mitochondria during aging
22. Isolation, culture, and characterization of epithelial cells derived from rat ventral prostate
23. Oxygen consumption by mitochondria from an endotherm and an ectotherm
24. Bioenergetic theory of prostate malignancy
25. The prostate secretion
26. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or scr oncogenes
27. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription
28. Glycolysis, respiration and anomalous gene expression in experimental hepatomas. G.H.A. Clowes memorial lecture
29. Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa
30. Evaluation of usefulness of in vitro drug sensitivity testing for adjuvant chemotherapy of stomach cancer
31. 3-Nitroprotionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants
32. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
33. ATP channel
34. 3-gossypol in organelles of cultured bovine luteal cells