VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2

British Journal of Pharmacology

Volumn 134, Issue 1, 2001, Pages 197-205

  Bernatchez, Pascal N ^a   Winstead, Michelle V ^b   Dennis, Edward A ^b   Sirois, Martin G ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Inflammation; PAF; VEGF

Indexed keywords

ENZYME INHIBITOR; LY 311727; PHOSPHOLIPASE A2; SANGUINARINE; SB 203347; SKF 45905; THROMBOCYTE ACTIVATING FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VESSEL TONE; ENZYME RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0034839972     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704215     Document Type: Article

References (53)

1. 2 by bromoenol lactone and trifluoromethyl ketones
2. 2 involved in arachidonic acid mobilization in murine P388DI macrophages
3. 2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages
4. 2
5. Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages
6. 2
7. VEGF effect on endothelial cell proliferation migration and PAF synthesis is mediated through the activation of Flk-1 receptor
8. 2 enzymes have different intracellular locations in mouse bone marrow-derived mast cells
9. Platelet-activating factor produced by endothelial cells: A molecule with autocrine and paracrine properties
10. Platelet-activating factor directly stimulates in vitro migration of endothelial cells and promotes in vivo angiogenesis
11. 2+-calmodulin and protein kinase C: A hypothetical synthesis of their conflicting convergences on shared substrate domains
12. 2
13. 2
14. 2
15. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
16. 2 by scalaradial
17. 2
18. 2 superfamily of signal transduction enzymes
19. Identification and characterization of the blood vesseles of solid tumors that are leaky to circulating macromolecules
20. Vascular endothelial growth factor. The trigger for neovascularization in the eye
21. What is the evidence that tumors are angiogenesis-dependent?
22. Angiogenic factors
23. 2 is essential for both the immediate and delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells
24. 2
25. The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis
26. The codependence of angiogenesis and chronic inflammation
27. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
28. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor bearing mice and cancer patients
29. 2
30. 2 enzymes in human monocyte eicosanoid formation
31. 2 does not alter leukotriene formation
32. 2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxic choc
33. 2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation
34. Inhibition of collagen-induced platelet activation by arachidonyl trifluoromethyl ketone
35. Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model
36. 2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms
37. Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model
38. 2
39. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
40. 2 that mediates prostaglandine production in mast cells
41. VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor
42. 2 enzymes: Classification and characterization
43. Biosynthesis of Platelet-activating factor and enzyme inhibitors
44. The role of transacylase in the metabolism of arachidonate and platelet activating factor
45. Macrophages and angiogenesis
46. 2 gene family in mammals
47. Platelet-activating factor: A phospholipid autacoid with diverse actions
48. The regulation of Platelet-activating Factor production in endothelial cells
49. Endothelium from diverse vascular sources synthesizes platelet-activating factor
50. 2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes
51. Pharmacology of CoA-independent transacylase
52. Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60
53. Inhibitors of arachidonate metabolism and effects on PAF production