Cloning and sequence analysis of cDNAs encoding the heavy and light chain variable regions of an Ab2β anti-idiotypic monoclonal antibody possessing an internal image of cocaine

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1521, Issue 1-3, 2001, Pages 135-140

  Ho, Mitchell ^a   Segre, Mariangela ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Anti idiotypic monoclonal antibody; Cocaine; Dopamine transporter; Nucleotide sequence

Indexed keywords

AMINO ACID; COCAINE; COMPLEMENTARY DNA; DOPAMINE; DOPAMINE TRANSPORTER; ENZYME ANTIBODY; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE ANTIBODY; MONOCLONAL ANTIBODY; NORADRENALIN; PROTEINASE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CAENORHABDITIS ELEGANS; DNA SEQUENCE; DROSOPHILA MELANOGASTER; GENETIC CODE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOFLUORESCENCE MICROSCOPY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CLONING, MOLECULAR; COCAINE; DNA, COMPLEMENTARY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EPITOPES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RATS; SEQUENCE ALIGNMENT;

EID: 0035980282     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(01)00253-6     Document Type: Article

References (24)

1. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter
2. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions
3. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding
4. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters
5. Exploring the feasibility of an anti-idiotypic cocaine vaccine: Analysis of the specificity of anti-cocaine antibodies (Ab1) capable of inducing Ab2β anti-idiotypic antibodies
6. A novel approach to the treatment of cocaine addiction: Possible use of anti-idiotypic antibodies as cocaine analog peptide drugs
7. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic Ab2β antibodies mimicking the configuration of cocaine
8. Towards a network theory of the immune system
9. Molecular basis of antigen mimicry by anti-idiotope
10. Idiotypic mimicry and the assembly of a supramolecular structure: An anti-idiotypic antibody that mimics taxol in its tubulin-microtubule interactions
11. Individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines
12. The attractions of proteins for small molecules and ions
13. Measurement of antibody affinity for cell surface antigens using an enzyme-linked immunosorbent assay
14. Kabat database and its applications: Future directions
15. Universal PCR amplification of mouse immunoglobulin gene variable regions: The design of degenerate primers and an assessment of the effect of DNA polymerase 3′ to 5′ exonuclease activity
16. IMGT, the international ImMunoGeneTics database
17. Structural relationships among mouse and human immunoglobulin VH genes in the subgroup III
18. Three-dimensional structure of an Fab-peptide complex: Structural basis of HIV-1 protease inhibition by a monoclonal antibody
19. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
20. The internal image and the structural idiotypic network (Ab1, Ab2, Ab3) in the GAT system
21. Two V kappa germ-line genes related to the GAT idiotypic network (Ab1 and Ab3/Ab1′) account for the major subfamilies of the mouse V kappa-1 variability subgroup
22. The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes
23. Molecular basis of an isogeneic anti-idiotypic response