Three-dimensional structure of an Fab-peptide complex: Structural basis of HIV-1 protease inhibition by a monoclonal antibody

Journal of Molecular Biology

Volumn 267, Issue 5, 1997, Pages 1207-1222

  Lescar, Julien ^a   Stouracova, Renata ^a,b   Riottot, Marie Madeleine ^a   Chitarra, Véronique ^a   Brynda, Jiri ^a,b   Fabry, Milan ^b   Horejsi, Magda ^b   Sedlacek, Juraj ^b   Bentley, Graham A ^a  

^a INSTITUT PASTEUR   (France)

^b INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

Antibody cross reactivity; Crystal structure; Enzyme inhibition; Fab fragment; HIV 1 protease

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PROTEINASE; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANTIBODY COMBINING SITE; ARTICLE; BETA CHAIN; COMPARATIVE STUDY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; DISSOCIATION CONSTANT; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE;

EID: 0031576997     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.0950     Document Type: Article

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