Clinical implications for affected parents and siblings of probands with long-QT syndrome

Circulation

Volumn 104, Issue 5, 2001, Pages 557-562

  Kimbrough, John ^a   Moss, Arthur J ^b   Zareba, Wojciech ^b   Robinson, Jennifer L ^b   Hall, W Jackson ^b   Benhorin, Jesaia ^c   Locati, Emanuela H ^d   Medina, Aharon ^c   Napolitano, Carlo ^f   Priori, Silvia ^f   Schwartz, Peter J ^e   Timothy, Katherine ^g   Towbin, Jeffrey A ^h   Vincent, G Michael ^g   Zhang, Li ^g  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c BIKUR CHOLIM HOSPITAL   (Israel)

^d UNIVERSITY OF PERUGIA   (Italy)

^e UNIVERSITY OF PAVIA   (Italy)

^f IRCCS   (Italy)

^g LDS HOSPITAL   (United States)

^h BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Electrocardiography; Genetics; Long QT syndrome; Risk factors; Sex

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL FEATURE; DISEASE SEVERITY; ELECTROCARDIOGRAPHY; FAMILY HISTORY; FEMALE; GENETIC SELECTION; HEART ARRHYTHMIA; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RELATIVE; RISK FACTOR; SEX DIFFERENCE; SIBLING;

EID: 0035979345     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3001.093501     Document Type: Article

References (16)

1. Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11
2. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
3. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
4. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
5. Mapping of a gene for long QT syndrome to chromosome 4q25-27
6. Mutations in the hminK gene cause long QT syndrome and suppress IKs function
7. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
8. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome
9. Influence of genotype on the clinical course of the long-QT syndrome
10. Genotype-phenotype correlation in the long-QT syndrome: Gene-specific triggers for life-threatening arrhythmias
11. The long QT syndrome: Genetic considerations
12. Regression models and life-tables
13. Low penetrance in the long QT syndrome: Clinical impact
14. Risk of cardiac events in family members of patients with long QT syndrome
15. Age and gender-related differences in cardiac events in patients with congenital long QT syndrome: Findings from the International LQTS Registry
16. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome