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unpublished results
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The major isomer, 7, can be clearly identified by a NOE between the methyl and the benzyloxymethylene protons: Ko, R. Y. Y., unpublished results.
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0042204637
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note
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2AlCl uniformly failed to produce the desired Weinreb amide.
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30
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0043206924
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note
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Compound 12 is presumably derived from the attack of the oxazolidone carbonyl by peroxide, reduction by sufite to the acyl carbamic acid, and decarboxylation.
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31
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0043206925
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note
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Using either DCC or BOP as coupling reagents, amide formation required 3-4 days and resulted in product yields of 44% and 36%, respectively.
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(a) Kitagaki, S.; Anada, M.; Kataoka, O.; Matsuno, K.; Umeda, C.; Watanabe, N.; Hashimoto, S. J. Am. Chem. Soc. 1999, 121, 1417.
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