Crystal Structures of the Transposon Tn5-carried Bleomycin Resistance Determinant Uncomplexed and Complexed with Bleomycin

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 9992-9999

  Maruyama, Masafumi ^a   Kumagai, Takanori ^a   Matoba, Yasuyuki ^a   Hayashida, Minoru ^a   Fujii, Tomomi ^b   Hata, Yasuo ^b   Sugiyama, Masanori ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CRYSTAL STRUCTURE; DIMERS; DNA; GENES; X RAY CRYSTALLOGRAPHY;

METAL IONS;

BIOCHEMISTRY;

2,3 DIAMINOPROPIONIC ACID; AMINE; AMINO ACID; BLEOMYCIN; GENE PRODUCT; GLUTAMINE; METAL ION; PROTEIN BLMT; THREONINE; UNCLASSIFIED DRUG; ACYLTRANSFERASE; BACTERIAL PROTEIN; BLEOMYCIN N ACETYLTRANSFERASE; BLEOMYCIN N-ACETYLTRANSFERASE; DNA; LIGAND; THIAZOLE DERIVATIVE; TRANSPOSASE;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; TRANSPOSON; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG RESISTANCE; GENETICS; HYDROGEN BOND; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

TRANSPOSON TN5; TRANSPOSONS;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BLEOMYCIN; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG RESISTANCE, NEOPLASM; GLUTAMINE; HYDROGEN BONDING; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THIAZOLES; THREONINE; TRANSPOSASES;

EID: 0035971192     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009874200     Document Type: Article

References (50)

1. Blum, R. H., Carter, S. K., and Agre, K. (1973) Cancer 31, 903-914
2. Umezawa, H. (1974) Fed. Proc. 33, 2296-2301
3. Stubbe, J., and Kozarich, J. W. (1987) Chem. Rev. 87, 1107-1136
4. Burger, M. R., Peisach, J., and Horwitz, S. B. (1981) J. Biol. Chem. 256, 11636-11644
5. Magliozzo, R. S., Peisach, J., and Ciriolo, M. R. (1989) Mol. Pharmacol. 35, 428-432
6. Carter, B. J., de Vroom, E., van der Marel, G. A., van Boom, J. H., and Hecht, S. M. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 9373-9377
7. Holmes, C. E., Carter, B. J., and Hecht, S. M. (1993) Biochemistry 32, 4293-4307
8. Sugiyama, M., Thompson, C. J., Kumagai, T., Suzuki, K., Deblaere, R., Villarroel, R., and Davies, J. (1994) Gene 151, 11-16
9. Sugiyama, M., Kumagai, T., Matsuo, H., Bhuiyan, M. Z. A., Ueda, K., Mochizuki, H., Nakamura, N., and Davies, J. E. (1995) FEBS Lett. 362, 80-84
10. Gatignol, A., Durand, H., and Tiraby, G. (1988) FEBS Lett. 230, 171-175
11. Bhuiyan, M. Z. A., Ueda, K., Inouye, Y., and Sugiyama, M. (1995) Appl. Microbiol. Biotechnol. 43, 65-69
12. Berg, D. E., Davies, J., Allet, B., and Rochaix, J. D. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 3628-3632
13. Genilloud, O., Ggarrido, M. C., and Moreno, F. (1984) Gene 32, 225-233
14. Mazodier, P., Cossart, P., Giraud, E., and Gasser, F. (1985) Nucleic Acids Res. 13, 195-205
15. Blot, M., Meyer, J., and Arber. W. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9112-9116
16. Blot, M., Hauer, B., and Monet, G. (1994) Mol. Gen. Genet. 242, 595-601
17. Kumagai, T., Nakano, T., Maruyama, M., Mochizuki, H., and Sugiyama, M. (1999) FEBS Lett. 442, 34-38
18. Adam, E., Volkert, M. R., and Blot, M. (1998) Mol. Microbiol. 28, 15-24
19. Kawano, Y., Kumagai, T., Muta, K., Matoba, Y., Davies, J., and Sugiyama, M. (2000) J. Mol. Biol. 295, 915-925
20. Dumas, P., Bergdoll, M., Cagnon, C., and Masson, J. M. (1994) EMBO J. 13, 2483-2492
21. Wu, W., Vanderwall, D. E., Turner, C. J., Kozarich, J. W., and Stubbe, J. (1996) J. Am. Chem. Soc. 118, 1281-1294
22. Vanderwall, D. E., Lui, S. M., Wu, W., Turner, C. J., Kozarich, J. W., and Stubbe, J. (1997) Chem. Biol. 4, 373-387
23. Kumagai, T., Maruyama, M., Matoba, Y., Kawano, Y., and Sugiyama, M. (1999) Acta Crystallogr. Sect. D 55, 1095-1097
24. McPherson, A. (1982) Preparation and Analysis of Protein Crystals, 1st ed., 96-97, John Wiley, New York
25. Matthews, B. W. (1968) J. Mol. Biol. 33, 491-497
26. Sakabe, N., Ikemizu, S., Sakabe, K., Higashi, T., Nakagawa, A., Watanabe, N., Adachi, S., and Sakaki, K. (1995) Rev. Sci. Instrum. 66, 1276-1281
27. Higashi, T. (1989) J. Appl. Crystallogr. 16, 542-547
28. Fox, G. C., and Holmes, K. C. (1966) Acta Crystallogr. 20, 886-891
29. Brünger, A. T. (1992) X-PLOR Version 3.1: a system for x-ray crystallography and NMR, Yale University Press, New Haven, CT
30. Brünger, A. T., Kuriyan, J., and Karplus, M. (1987) Science 235, 458-460
31. Konnert, J. H., and Hendrickson, W. A. (1980) Acta Crystallogr. Sect. A 36, 344-350
32. Brünger, A. T. (1992) Nature 355, 472-475
33. Wilson, A. J. C. (1942) Nature 150, 152
34. McRee, D. E. (1992) J. Mol. Graph. 10, 44-46
35. Sheldrick, G. M., and Schneider, T. R. (1997) Methods Enzymol. 277, 319-343
36. Luzzati, V. (1952) Acta Crystallogr. 5, 802-810
37. Ramachandran, G. N., and Sasisekharan, V. (1968) Adv. Protein Chem. 23, 283-438
38. Kleywegt, G. J., and Jones, T. A. (1996) Structure 4, 1395-1400
39. Jiang, J. S., and Brünger, A. T. (1994) J. Mol. Biol. 243, 100-115
40. Iitaka, Y., Nakamura, H., Nakatani, T., Muraoka, Y., Fujii, A., Takita, T., and Umezawa, H. (1978) J. Antibiot. (Tokyo) 31, 1070-1072
41. Kuroda, R., Neidle, S., Riordan, J. M., and Sakai, T. T. (1982) Nucleic Acids Res. 10, 4753-4763
42. James, M. N., and Watson, K. J. (1996) J. Chem. Soc. 16, 1361-1371
43. Sakai, T. T., Riordan, J. M., Booth, T. E., and Glickson, J. D. (1981) J. Med. Chem. 24, 279-285
44. Lin, S. Y., and Grollman, A. P. (1981) Biochemistry 20, 7589-7598
45. Wu, W., Vanderwall, D. E., Lui, S. M., Tang, X. J., Turner, C. J., Kozarich, J. W., and Stubbe, J. (1996) J. Am. Chem. Soc. 118, 1268-1280
46. Lehmann, T. E., Ming, L. J., Rosen, M. E., and Que, L., Jr. (1997) Biochemistry 36, 2807-2816
47. Xu, R. X., Nettesheim, D., Otvos, J. D., and Petering, D. H. (1994) Biochemistry 33, 907-916
48. Caceres-Cortes, J., Sugiyama, H., Ikudome, K., Saito, I., and Wang, A. H. (1997) Eur. J. Biochem. 244, 818-828
49. Akkermann, M. A. J., Neijman, E. W. J. F., Wijmenga, S. S., Hilbers, C. W., and Bernal, W. (1990) J. Am. Chem. Soc. 112, 7462-7474
50. Akkermann, M. A. J., Haasnoot, C. A. G., and Hilbers, C. W. (1988) Eur. J. Biochem. 173, 211-225