Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5′-upstream regions of these genes

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 247-260

  Sreerama, Lakshmaiah ^a   Sládek, Norman E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aldehyde dehydrogenase; ALDH3A1; Benz(a)pyrene; Catechol; Drug resistance; Electrophile responsive element EpRE ; Indole 3 carbinol; Mafosfamide; Oxazaphosphorines

Indexed keywords

3 INDOLEMETHANOL; 4 HYDROPEROXYCYCLOPHOSPHAMIDE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3A1; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CYCLOPHOSPHAMIDE; MAFOSFAMIDE; OXAZAPHOSPHORINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONFERENCE PAPER; CONTROLLED STUDY; DETOXIFICATION; DRUG METABOLISM; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PROTEIN EXPRESSION; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR RESISTANCE;

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; BREAST NEOPLASMS; DNA PRIMERS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHORAMIDE MUSTARDS; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; UP-REGULATION;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035969877     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00269-6     Document Type: Conference Paper

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