Multienzyme-mediated stable and transient multidrug resistance and collateral sensitivity induced by xenobiotics

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 3, 1997, Pages 215-224

  Rekha, Ganaganur K ^a   Sladek, Norman E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aldehyde dehydrogenase; Bifunctional inducers; Breast cancer; Cyclophosphamide; Cytochrome P450 1A1; Doxorubicin; DT diaphorase; Ellipticine; EO9; Glutathione S transferase; Ifosfamide; Mafosfamide; Melphalan; Mitoxantrone; Monofunctional inducers; Multidrug collateral sensitivity; Multidrug resistance; Oxazaphosphorines; Phase 1 drug metabolizing enzymes; Phase 2 drug metabolizing enzymes; UDP glucuronosyl transferase; Vincristine

Indexed keywords

3 METHYLCHOLANTHRENE; ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; CATECHOL; CYCLOPHOSPHAMIDE; DOXORUBICIN; ELLIPTICINE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; IFOSFAMIDE; MAFOSFAMIDE; MELPHALAN; MITOXANTRONE; PHOSPHORAMIDE MUSTARD; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); VINCRISTINE; XENOBIOTIC AGENT;

ARTICLE; BREAST ADENOCARCINOMA; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; MODEL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ADENOCARCINOMA; ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOGENS; CATECHOLS; CYTOCHROME P-450 CYP1A1; DRUG RESISTANCE, MULTIPLE; ENZYME INDUCTION; FEMALE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HUMANS; METHYLCHOLANTHRENE; NAD(P)H DEHYDROGENASE (QUINONE); SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; XENOBIOTICS;

EID: 0030958469     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050649     Document Type: Article

References (58)

1. Asman DC, Takimoto K, Pitot HC, Dunn TJ, Lindhal R (1993) Organization and characterization of the rat class 3 aldehyde dehydrogenase gene. J Biol Chem 268: 12530
2. 1 (DT-diaphorase) expression in normal and tumor tissues. Cancer Metastasis Rev 12: 103
3. Benson AB III (1993) Oltipraz: a laboratory and clinical review. J Cell Biochem [Suppl] 17F: 278
4. Bock KW (1991) Roles of UDP-glucuronosyltransferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 26: 129
5. Bock KW, White INH (1974) UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene. Eur J Biochem 46: 451
6. Bock KW, Lipp H-P, Bock-Hennig BS (1990) Induction of drug-metabolizing enzymes by xenobiotics. Xenobiotica 20: 1101
7. Bradfield CA, Bjeldanes LF (1991) Modification of carcinogen metabolism by indolylic autolysis products of Brassica oleraceae. Adv Exp Med Biol 289: 153
8. Bunting KD, Townsend AJ (1996) Protection by transfected rat or human class 3 aldehyde dehydrogenases against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. J Biol Chem 271: 11891
9. Bunting KD, Lindahl R, Townsend AJ (1994) Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase. J Biol Chem 269: 23197
10. Burchell B, Baird S, Coughtrie MWH (1991) The role of xenobiotic glucuronidating enzymes in drug resistance of tumor tissues and cells. In: Ernster L, Esumi H, Fujii Y, Gelboin HV, Kato R, Sugimura T (eds) Xenobiotics and cancer. Taylor & Francis, London, p 263
11. Burger H, Nooter K, Zaman GJR, Sonneveld P, van Wingerden KE, Oostrum RG, Stoter G (1994) Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia 8: 990
12. Childs S, Ling V (1994) The MDR superfamily of genes and its biological implications. In: DeVita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology. Lippincott, Philadelphia, p 21
13. Ciaccio PJ, Jaiswal AK, Tew KD (1994) Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. J Biol Chem 269: 15558
14. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650
15. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137
16. Ernster L (1967) DT diaphorase. Methods Enzymol 10: 309
17. Flens MJ, Zaman GJR, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJLM, Scheper RJ (1996) Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237
18. Frei E III, Teicher BA, Holden SA, Cathcart KNS, Wang Y (1988) Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res 48: 6417
19. Giai M, Biglia N, Sismondi P (1991) Chemoresistance in breast tumors. Eur J Gynaecol Oncol 12: 359
20. Goldstein LJ (1995) Clinical reversal of drug resistance. In: Ozols RF (ed) Current problems in cancer. Mosby-Year Book, St. Louis, p 67
21. Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SPC. Deeley RG (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54: 357
22. Hales BF (1982) Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard and acrolein. Cancer Res 42: 3016
23. Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST* and the contribution of the isozymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30: 445
24. Hornbeck P, Winston SE, Fuller SA (1991) Enzyme-linked immunosorbent assays (ELISA). In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) Current protocols in molecular biology, vol 2. Greene Publishing Associates and Wiley-Interscience, New York, p 11.2.1
25. Izquierdo MA, van der Zee AGJ, Vermorken JB, van der Valk P, Beliën JAM, Giaccone G, Scheffer GL, Flens MJ, Pinedo HM, Kenemans P, Meijer CJLM, de Vries EGE, Scheper RJ (1995) Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J Natl Cancer Inst 87: 1230
26. Jaiswal AK (1994) Jun and Fos regulation of NAD(P)H: quinone oxidoreductase gene expression. Pharmacogenetics 4: 1
27. Kelley MK, Engqvist-Goldstein A, Montali JA, Wheatley JB, Schmidt DE Jr, Kauvar LM (1994) Variability of glutathione S-transferase isoenzyme patterns in matched normal and cancer human breast tissue. Biochem J 304: 843
28. Kelloff GJ, Boone CW, Steele VE, Fay JR, Lubet RA, Crowell JA, Sigman CC (1994) Mechanistic considerations in chemopreventive drug development. J Cell Biochem [Suppl] 20: 1
29. List AF, Spier CS, Abbaszadegan M, Grogan TM, Greer JP, Wolff SN, Scheper RJ, Dalton WS (1993) Non-P-glycoprotein (PGP) mediated multidrug resistance (MDR): identification of a novel drug resistance phenotype with prognostic relevance in acute myeloid leukemia (AML) (abstract). Blood 82 [Suppl I]: 443a
30. Mackenzie PI, Hänninen O (1980) A sensitive kinetic assay for UDPglucuronosyltransferase using 1-naphthol as substrate. Anal Biochem 109: 362
31. Murray GI, Weaver RJ, Paterson PJ, Ewen SWB, Melvin WT, Burke MD (1993) Expression of xenobiotic metabolizing enzymes in breast cancer. J Pathol 169: 347
32. Murren JR, Hait WN (1992) Why haven't we cured multidrug resistant tumors? Oncol Res 4: 1
33. 1-450 (CYP1A1) gene, Int J Biochem 21: 243
34. Paoletti C, Auclair C, Lesca P, Tocanne JF, Malvy C, Pinto M (1981) Ellipticine, 9-hydroxyellipticine, and 9-hydroxyellipticinium: some biochemical properties of possible pharmacologic significance. Cancer Treat Rep 65 [Suppl 3]: 107
35. Peters WHM, Roelofs HMJ (1992) Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases. Cancer Res 52: 1886
36. Ploemen JHTM, van Ommen B, Bogaards JJP, van Bladeren PJ (1993) Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases. Xenobiotica 23: 913
37. Rekha GK, Sreerama L, Sladek NE (1994) Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase. Biochem Pharmacol 48: 1943
38. Rushmore TH, Morton MR, Pickett CB (1991) The antioxidant responsive element: activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 266: 11632
39. Sartorelli AC, Hodnick WF, Belcourt MF, Tomasz M, Haffty B, Fischer JJ, Rockwell S (1994) Mitomycin C: a prototype bioreductive agent. Oncol Res 6: 501
40. r 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res 53: 1475
41. Shen Z, Liu J, Wells RL, Elkind MM (1994) cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene. Cyp1b1. DNA Cell Biol 13: 763
42. Sladek NE (1993) Oxazaphosphorine-specific acquired cellular resistance. In: Teicher BA (ed) Drug resistance in oncology. Marcel Dekker, New York, p 375
43. Sladek NE (1994) Metabolism and pharmacokinetic behavior of cyclophosphamide and related oxazaphosphorines. In: Powis G (ed) Anticancer drugs: reactive metabolism and drug interactions. Pergamon Press, Oxford, United Kingdom, p 79
44. Sladek NE, Sreerama L (1995) Cytosolic class-3 and class-1 aldehyde dehydrogenase activities (ALDH-3 and ALDH-1. respectively) in human primary breast tumors (abstract). Proc Am Assoc Cancer Res 36: 325
45. Sladek NE, Sreerama L, Rekha GK (1995) Constitutive and overexpressed human cytosolic class-3 aldehyde dehydrogenases in normal and neoplastic cells secretions. Adv Exp Med Biol 372: 103
46. Sreerama L, Sladek NE (1993) Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance. Biochem Pharmacol 45: 2487
47. Sreerama L, Sladek NE (1993) Overexpression or polycyclic aromatic hydrocarbon-mediated induction of an apparently novel class 3 aldehyde dehydrogenase in human breast adenocarcinoma cells and its relationship to oxazaphosphorine-specific acquired resistance. Adv Exp Med Biol 328: 99
48. Sreerama L, Sladek NE (1994) Identification of a methylcholanthrene-induced aldehyde dehydrogenase in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance. Cancer Res 54: 2176
49. Sreerama L, Sladek NE (1995) Human breast adenocarcinoma MCF-7/0 cells electroporated with cytosolic class 3 aldehyde dehydrogenases obtained from tumor cells and a normal tissue exhibit differential sensitivity to mafosfamide. Drug Metab Dispos 23: 1080
50. Sreerama L, Hedge MW, Sladek NE (1995) Identification of a class 3 aldehyde dehydrogenase in human saliva and increased levels of this enzyme, glutathione S-transferases and DT-diaphorase in the saliva of the subjects who continually ingest large quantities of coffee or broccoli. Clin Cancer Res 1: 1153
51. Sreerama L, Rekha GK, Sladek NE (1995) Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance. Biochem Pharmacol 49: 669
52. Talalay P, De Long MJ, Prochaska HJ (1987) Molecular mechanisms in protection against carcinogenesis. In: Cory JG, Szentivani A (eds) Cancer biology and therapeutics. Plenum Press, New York. p 197
53. Testa B, Jenner P (1981) Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metab Rev 12: 1
54. Townsend AJ, Goldsmith ME, Pickett CB, Cowan KH (1989) Isolation, characterization, and expression in Escherichia coli of two murine mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2). J Biol Chem 264: 21582
55. Wattenberg LW (1985) Chemoprevention of cancer. Cancer Res 45: 1
56. Wiebel FJ (1980) Activation and inactivation of carcinogens by microsomal monooxygenases: modification by benzoflavones and polycyclic aromatic hydrocarbons. In: Slaga TJ (ed) Carcinogenesis - a comprehensive survey, vol 5. Raven Press, New York, p 57
57. Wolf CR, Macpherson JS, Smyth JF (1986) Evidence for the metabolism of mitozantrone by microsomal glutathione transferases and 3-methylcholanthrene-inducible glucuronosyl transferases. Biochem Pharmacol 35: 1577
58. Workman P (1994) Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res 6: 461