Crystal structure of thiamin pyrophosphokinase

Journal of Molecular Biology

Volumn 310, Issue 1, 2001, Pages 195-204

  Timm, David E ^a   Liu, Jingyuan ^a   Baker, L J ^a   Harris, Robert A ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Crystal structure; Kinase; Metabolism; Thiamin; Vitamin

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; ANTIINFECTIVE AGENT; COCARBOXYLASE; DIMER; GLUCOSE; POLYPEPTIDE; PYROPHOSPHATE; THIAMINE; THIAMINE PYROPHOSPHOKINASE;

ARTICLE; BERIBERI; BETA SHEET; CATALYSIS; CITRIC ACID CYCLE; COENZYME; CRYSTAL STRUCTURE; ENZYME STRUCTURE; EUKARYOTE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SEQUENCE HOMOLOGY; WERNICKE ENCEPHALOPATHY;

EID: 0035967919     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4727     Document Type: Article

References (36)

1. Thiamin
2. Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: Genetic regulation
3. Interplay of organic and biological chemistry in understanding coenzyme mechanisms: Example of thiamin diphosphate-dependent decaroxylations of 2-oxo acids
4. Thiamin and thiamin phosphate ester deficiency assessed by HPLC in four clinical cases of Wernicke encephalopathy
5. Effects of acute and chronic ethanol administration of regional thiamin pyrophophokinase activity of the rat brain
6. Effects of acute and chronic ethanol administration on thiamine metabolizing enzymes in some brain areas and in other organs of the rat
7. Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae
8. Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, and growth
9. Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction
10. Thiamin pyrophosphokinase: Structure, properties and role in thiamin metabolism
11. Thiamin pyrophosphokinase. Purification, properties, and function
12. Purification and proerties of thiamine pyrophophokinase from parsely leaf
13. Thiamine as an integral component of brain synaptosomal membranes
14. Purification and properties of thiamine pyrophosphokinase
15. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA
16. Structure of ribonuclease H phased at 2 Å resolution by MAD analysis of the selenomethionyl protein
17. A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase
18. The crystal structure of benzoylformate decarboxylase at 1.6 Å resolution: Diversity of catalytic residues in thiamin diphosphate-dependent enzymes
19. Crystal structure of 2-oxoisovalerate dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes
20. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 Å resolution
21. Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 Å resolution
22. Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 Å resolution
23. How thiamine diphosphate is activated in enzymes
24. Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase
25. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents
26. Chemical and biological evolution of a nucleotide binding protein
27. Rm1C, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase
28. High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer
29. The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold
30. Processing of X-ray diffraction data collected in oscillation data reduction mode
31. Automated structure solution for MIR and MAD
32. Collaborative Computing Project No. 4. The CCP4 suite of programs
33. Improved methods for building protein models in electron density maps and the location of errors in these models
34. Crystallography & NMR system: A new software suite for macromolecular structure determination
35. TOP: A new method for structure comparisons and similarity searches
36. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures