Enzymatic resolution of trans-4-(4′-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (-)-Paroxetine

Journal of Organic Chemistry

Volumn 66, Issue 26, 2001, Pages 8947-8953

  De Gonzalo, G ^a   Brieva, R ^a   Sanchez V M ^a,b   Bayod, M ^a,b   Gotor, V ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Astur Pharma S A Polígono Industrial de Silvota ^*  (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOMERS; LIPASES;

ACYLATION; CATALYSIS; ENZYMES; ISOMERS; ORGANIC SOLVENTS;

SYNTHESIS (CHEMICAL);

4 (4' FLUOROPHENYL) 3 HYDROXYMETHYLPIPERIDINE DERIVATIVE; ORGANIC SOLVENT; PAROXETINE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CANDIDA ANTARCTICA; CATALYSIS; ENANTIOMER; ENZYME ACTIVITY; ISOMERISM; STEREOCHEMISTRY; SYNTHESIS;

ACETYLATION; BENZENE DERIVATIVES; CANDIDA; HYDROLYSIS; INDICATORS AND REAGENTS; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; PAROXETINE; PIPERIDINES; SOLVENTS; STEREOISOMERISM;

EID: 0035966161     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo010809+     Document Type: Article

References (17)