Improved synthesis of paroxetine hydrochloride propan-2-ol solvate through one of metabolites in humans, and characterization of the solvate crystals

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 4, 2000, Pages 529-536

  Sugi, Kiyoshi ^a   Itaya, Nobushige ^a   Katsura, Tadashi ^a   Igi, Masami ^a   Yamazaki, Shigeya ^a   Ishibashi, Taro ^a   Yamaoka, Teiji ^a   Kawada, Yoshihiro ^a   Tagami, Yayoi ^a   Otsuki, Michiya ^a   Ohshima, Takao ^a  

^a Sumika Fine Chemicals Co Ltd   (Japan)

Author keywords

Paroxetine; Paroxetine hydrochloride

Indexed keywords

2 PROPANOL; PAROXETINE;

ARTICLE; CRYSTAL STRUCTURE; DERIVATIZATION; DRUG SYNTHESIS; ENANTIOMER; SOLVATION; THERMAL ANALYSIS; THERMODYNAMICS; X RAY DIFFRACTION;

EID: 0034015917     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.529     Document Type: Article

References (16)

1. Drugs Fut., 11, 112-115 (1986).
2. Haddock R. E., Johnson A. M., Langley P. F., Nelson D. R., Pope J. A., Thomas D. R., Woods F. R., Acta Psychiatr. Scand., 80 (supp. 350), 24-26 (1989).
3. a) Christensen J. A., Squires R. F., Ger. Offen. DE 2404113 (1974) [Chem. Abstr., 81, 152011q (1974);
4. b) Barnes R. D., Wood-Kaczmar M. W., Richardson J. E., Lynch I. R., Buxton P. C., Curzons A. D., Eur. Pat. Appl. EP 223403 (1987) [Chem. Abstr., 107, 141102z (1987)];
5. c) Hansen J. B., Treppendahl S., Engelstoft M., Bentzen B., Lehmann S., PCT Int. Appl. WO 96 36636 (1996) [Chem. Abstr., 126, 59872j (1997)];
6. d) i; Wang S., Okazoe T., Matsumura Y., Mori N., Nishino J., Ookura K., Eur. Pat. Appl. EP 802185 (1997) [Chem. Abstr., 127, 358789b (1997)]; ii; Wang S., Matsumura Y., Eur. Pat. Appl. EP 810225 (1997) [Chem. Abstr., 128, 61506c (1998)].
7. d) i; Wang S., Okazoe T., Matsumura Y., Mori N., Nishino J., Ookura K., Eur. Pat. Appl. EP 802185 (1997) [Chem. Abstr., 127, 358789b (1997)]; ii; Wang S., Matsumura Y., Eur. Pat. Appl. EP 810225 (1997) [Chem. Abstr., 128, 61506c (1998)].
8. a) Amat M., Hidalgo J., Bosch J., Tetrahedron: Asymmetry, 7, 1591-1594, (1996);
9. b) Sugi K., Itaya N., Katsura T., Igi M., Yamazaki S., Ishibashi T., Yamaoka T., Kawada Y., Tagami Y., Eur. Pat. Appl. EP 812827 (1997) [Chem. Abstr., 128, 75308b (1998)];
10. Patil V. D., Viswanathan C. L., Indian Drugs, 35, 686-692 (1998) [Chem. Abstr., 130, 18232t (1999)].
11. Patil V. D., Viswanathan C. L., Indian Drugs, 35, 686-692 (1998) [Chem. Abstr., 130, 18232t (1999)].
12. Buxton P. C., Lynch I. R., Roe J. M., Int. J. Pharm., 42, 135-143 (1988).
13. Yokota M., Uekusa H., Ohashi Y., Bull. Chem. Soc. Jpn., 72, 1731-1736 (1999).
14. Koelsch C. F., J. Am. Chem. Soc., 65, 2459-2460 (1943).
15. Montzka T. A., Pindell T. L., Matiskella J. D., J. O. Chem., 33, 3393-3395 (1968).
16. Ward N., Jacewicz V. W., Ger. Offen. DE 19603797 (1996) [Chem. Abstr., 125, 204558y (1996)].