Effect of passive and iontophoretic skin pretreatments with terpenes on the in vitro skin transport of piroxicam

International Journal of Pharmaceutics

Volumn 229, Issue 1-2, 2001, Pages 37-44

  Doliwa, A ^a   Santoyo, S ^a   Ygartua, P ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Hydroxypropyl cyclodextrin:Px complexes; Iontophoresis; Skin pretreatment; Skin retention; Terpenes

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALCOHOL; CARBOMER; CARBOPOL ETD; CINEOLE; MENTHONE; PIROXICAM; THYMOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PENETRATION; DRUG TRANSPORT; GEL; IONTOPHORESIS; MORPHOLOGY; NONHUMAN; PASSIVE TRANSPORT; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PERMEABILITY;

ANIMALS; CYCLOOXYGENASE INHIBITORS; EXCIPIENTS; GELS; IONTOPHORESIS; PIROXICAM; POLYVINYLS; SKIN; SOLVENTS; STIMULATION, CHEMICAL; SWINE; TERPENES;

EID: 0035965498     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00849-3     Document Type: Article

References (29)

1. Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium
2. The influence of the physicochemical characteristics and pharmacokinetic properties of selected NSAID's on their transdermal absorption
3. Mechanism of transport enhancement of LHRH through porcine epidermis by terpenes and iontophoresis: Permeability and lipid extraction studies
4. Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis
5. Effect of penetration enhancers and iontophoresis on the ultrastructure and cholecystokinin-8 permeability through porcine skin
6. Characterization of the permeselective properties of excised human skin during iontophoresis
7. Characterization of convective solvent flow during iontophoresis
8. Influence of piroxicam: Hydroxypropyl-(-cyclodextrin complexation on the in vitro permeation and skin retention of piroxicam
9. The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities
10. Iontophoretic delivery of piroxicam across the skin in vitro
11. Transdermal iontophoresis: Modulation of electroosmosis by polypeptides
12. Convective solvent flow across the skin during iontophoresis
13. Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro
14. Analysis of skin permeation-enhancing mechanism of iontophoresis using hydrodynamic pore theory
15. Electrorepulsion versus electroosmosis: Effect of pH on the iontophoretic flux of 5-fluorouracil
16. A lamellar matrix model for stratum corneum intercellular lipids. V. Effects of terpene penetration enhancers on the structure and thermal behaviour of the matrix
17. Promoting effect of O-ethylmenthol on the percutaneous absorption of ketoprofen
18. Effect of limonene and related compounds on the percutaneous absorption of indomethacin
19. Percutaneous absorption enhancing effect and skin irritation of monocyclic terpenes
20. Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes
21. Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs
22. Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application
23. Piroxicam pharmacologic activity and gastrointestinal damage by oral and rectal route
24. Antiinflammatory activity and bioavailability of percutaneous piroxicam
25. Skin alteration and convective solvent flow effects during iontoforesis: I. Neutral solute transport across human skin
26. Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery
27. Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin
28. Terpenes and the lipid-protein-partitioning theory of the skin penetration enhancement
29. Skin absorption enhancers