Influence of piroxicam: Hydroxypropyl-beta-cyclodextrin complexation on the in vitro permeation and skin retention of piroxicam

Skin Pharmacology and Applied Skin Physiology

Volumn 14, Issue 2, 2001, Pages 97-107

  Doliwa, A ^a   Santoyo, Susana ^a   Ygartua, P ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Hydrophilic carbopol gels; Percutaneous permeation; Piroxicam:hydroxypropyl cyclodextrin complexes; Pretreatment studies; Release rate; Stability constants

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; PIROXICAM; PROPYLENE GLYCOL; SOLVENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; GEL; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOLID STATE; STOICHIOMETRY; X RAY DIFFRACTION;

ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CYCLODEXTRINS; EXCIPIENTS; MALE; PIROXICAM; RATS; SKIN ABSORPTION; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED;

EID: 0035027933     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056339     Document Type: Article

References (29)

1. The role of percutaneous penetration enhancers
2. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization
3. The effects of cyclodextrins on transdermal delivery of drugs
4. Medical applications of cyclodextrins
5. Cyclodextrin as permeation enhancers: Some theoretical evaluations and in vitro testing
6. Preparation, characterization, and evaluation of miconazole-cyclodextrin complexes for improved oral and topical delivery
7. Analgesic-antipyretics and anti-inflammatory agents: Drugs employed in the treatment of rheumatoid arthritis and gout
8. Piroxicam pharmacologic activity and gastrointestinal damage by oral and rectal route
9. Anti-inflammatory activity and bioavailability of percutaneous piroxicam
10. The influence of the physicochemical characteristics and pharmacokinetic properties of selected NSAIDs on their transdermal absorption
11. Enhanced efficacy by percutaneous absorption of piroxicam from the poloxamer gel in rats
12. Permeation of piroxicam from the poloxamer gels
13. Influence of non-ionic surfactants, pH and propylene glycol on percutaneous absorption of piroxicam from cataplasm
14. Penetration enhancer effects on the in vitro percutaneous absorption of piroxicam through rat skin
15. Phase solubility techniques
16. Mechanism of percutaneous absorption. I. Routes of penetration and the influence of solubility
17. Effects of ethanol on formation of inclusion complexes of hydroxypropylcyclodextrins with testosterone or with methyl orange
18. Characterization of itraconazole/2-hydroxypropyl-β-cyclodextrin inclusion complex in aqueous propylene glycol solution
19. A study of the inclusion complex of amphotericin-B with γ-cyclodextrin
20. Solid particulates of drug-β-cyclodextrin inclusion complexes directly prepared by a spry-drying technique
21. Influence of cyclodextrin complexation on the in vitro permeation and skin metabolism of dexamethasone
22. Biopharmaceutical characteristics of indomethacin gel ointment
23. On the determination of drug release rates from topical dosage forms
24. The effect of hydroxypropyl methylcellulose on the release of dexamethasone from aqueous 2-hydroxypropyl-β-cyclodextrin formulations
25. Physical chemical analysis of percutaneous absorption from creams and ointments
26. The effect of polyvinylpirrolidone on cyclodextrin complexation of hydrocortisone and its diffusion through hairless mouse skin
27. Enhancing effect of hydroxypropyl-β-cyclodextrin on cutaneous penetration and activation of ethyl 4-biphenylyl acetate in hairless mouse skin
28. Effects of cyclodextrins on skin: Implications for the transdermal delivery of piribedil and a novel cognition enhancing-drug
29. Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse