Molecular characterization of the pore-forming toxin, pyolysin, a major virulence determinant of Arcanobacterium pyogenes

Veterinary Microbiology

Volumn 82, Issue 3, 2001, Pages 261-274

  Billington, Stephen J ^a   Songer, J Glenn ^a   Jost, B Helen ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Antigens; Arcanobacterium pyrogenes; Pyolysin; Vaccination; Virulence

Indexed keywords

EXOTOXIN; PYOLYSIN; UNCLASSIFIED DRUG;

ARCANOBACTERIUM PYOGENES; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM; BACTERIUM IDENTIFICATION; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; ENZYME BINDING; GENE INACTIVATION; MOLECULAR CLONING; MOUSE; MUTANT; NONHUMAN; PERITONITIS;

ACTINOMYCES; ACTINOMYCETACEAE; ACTINOMYCETALES INFECTIONS; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL TOXINS; CYTOTOXICITY TESTS, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; HEMOLYSIN PROTEINS; MICE; MUTAGENESIS; VACCINATION; VIRULENCE;

ANIMALIA; ARCANOBACTERIUM; ARCANOBACTERIUM PYOGENES;

EID: 0035965087     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1135(01)00373-X     Document Type: Article

References (59)

1. Corynebacteria associated with diseases of cattle, sheep and goats in northern Nigeria
2. Virulence studies on the chromosomal α-toxin and θ-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of α-toxin in Clostridium perfringens-mediated gas gangrene
3. Characteristics of Actinomyces pyogenes involved in lameness of male turkeys in north-central United States
4. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
5. The Arcanobacterium (Actinomyces) pyogenes hemolysin, pyolysin, is a novel member of the thiol-activated cytolysin family
6. The Arcanobacterium (Actinomyces) pyogenes plasmid pAP1 is a member of the pIJ101/pJV1 family of rolling circle replication plasmids
7. Thiol-activated cytolysins: Structure, function and role in pathogenesis
8. Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae
9. Description of osteomyelitis lesions associated with Actinomyces pyogenes infection in the proximal tibia of adult male turkeys
10. The treatment of summer mastitis using Corynebacterium pyogenes toxoid
11. Corynebacterium pyogenes: The problem of vaccination against infection
12. Antibody response to and immunity induced by Corynebacterium pyogenes vaccine
13. Immunological studies with Corynebacterium pyogenes in mice
14. Purification and further characterization of a haemolysin of Actinomyces pyogenes
15. Two cases of Actinomyces pyogenes infection in humans
16. Identification and partial characterization of an Actinomyces pyogenes hemolysin
17. Human infections with Actinomyces pyogenes (Corynebacterium pyogenes)
18. Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae
19. Pathogenicity islands of virulent bacteria: Structure, function and impact on microbial evolution
20. Streptococcal shock syndrome: Synthesis of tumor necrosis factor and interleukin-1 by monocytes stimulated with pyrogenic exotoxin A and streptolysin O
21. Infection following challenge of the lactating and dry udder of dairy cows with Actinomyces pyogenes and Peptostreptococcus indolicus
22. Pneumolysin stimulates production of tumor necrosis factor-α and interleukin-1β by human mononuclear phagocytes
23. Failure of an Actinomyces pyogenes vaccine to protect sheep against an intravenous challenge
24. The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding
25. Corynebacterium pyogenes endocarditis. Report of a case with necropsy and review of the literature
26. Electroporation-mediated transformation of Arcanobacterium (Actinomyces) pyogenes
27. An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence
28. Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocytogenes: Activation of NF-KB and upregulation of adhesion molecules and chemokines
29. Activation of human effector cells by different bacterial toxins (leukocidin, alveolysin, and erythrogenic toxin A): Generation of interleukin-8
30. A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers
31. Corynebacterium pyogenes: Its pathogenic mechanism in leg ulcers in Thailand
32. Endemic leg ulcers caused by Corynebacterium pyogenes in Thailand
33. Untersuchungen zu möglichen Pathogenitätsfaktoren von Actinomyces pyogenes Übersichtsreferat
34. Bacteriologic and histologic studies of hepatic abscesses in cattle
35. The Corynebacterium pyogenes antitoxin content of animal sera
36. Further studies on the toxin of Corynebacterium pyogenes
37. Field trials with Corynebacterium pyogenes alum-precipitated toxoid
38. Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitution in listeriolysin O
39. Biological properties of pneumolysin
40. Streptococcal cytolysins
41. Intermedilysin, a novel cytotoxin specific for human cells, secreted by Streptococcus intermedius UNS46 isolated from a human liver abscess
42. Contribution of tryptophan residues to the structural changes in perfringolysin O during interaction with liposomal membranes
43. Biochemical and biological characterizations and ribotyping of Actinomyces pyogenes and Actinomyces pyogenes-like organisms from liver abscesses in cattle
44. Biochemical and ribotypic comparison of Actinomyces pyogenes and A. pyogenes-like organisms from liver abscesses, ruminal wall, and ruminal contents of cattle
45. Induction of cytokine gene expression by listeriolysin O and roles of macrophages and NK cells
46. Molecular determinants of Listeria monocytogenes pathogenesis
47. Phylogenetic analysis of the genus Actinomyces based on 16S rRNA gene sequences: Description of Arcanobacterium phocae sp. nov., Arcanobacterium bernardiae comb. nov., and Arcanobacterium pyogenes comb. nov
48. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
49. Uterine infections in the postpartum cow. II. Possible synergistic effect of Fusobacterium necrophorum and Corynebacterium pyogenes
50. Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci
51. Characterization of the extracellular neuraminidase produced by Actinomyces pyogenes
52. Isolation and characterization of an extracellular protease of Actinomyces pyogenes
53. Contribution of individual tryptophan residues to the structure and activity of θ-toxin (perfringolysin O), a cholesterol-binding cytolysin
54. Early abortion in cattle induced by experimental intrauterine infection with pure cultures of Actinomyces pyogenes
55. The mechanism of membrane insertion for a cholesterol-dependent cytolysin: A novel paradigm for pore-forming toxins
56. Experimental induction of renal lesions in chickens
57. Assay of proteases from Actinomyces pyogenes isolated from pigs and cows by zymography