CNA42 monoclonal antibody identifies FDC as PrPsc accumulating cells in the spleen of scrapie affected sheep

Veterinary Immunology and Immunopathology

Volumn 82, Issue 1-2, 2001, Pages 1-8

  Lezmi, S ^a   Bencsik, A ^a   Baron, T ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

Author keywords

CNA42 mAb; Follicular dendritic cells (FDC); Lymphoid tissue; Prion; Scrapie; Sheep

Indexed keywords

CELL PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CNA42; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DENDRITIC CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTION; LYMPH NODE; LYMPHOID ORGAN; NONHUMAN; OVARY FOLLICLE CELL; PRION DISEASE; PROTEIN LOCALIZATION; SCRAPIE; SHEEP; SPLEEN; TONSIL;

ANIMALS; ANTIBODIES, MONOCLONAL; DENDRITIC CELLS, FOLLICULAR; IMMUNOHISTOCHEMISTRY; PRPSC PROTEINS; SCRAPIE; SHEEP; SPLEEN;

MURINAE; OVIS ARIES;

EID: 0035965026     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(01)00323-3     Document Type: Article

References (22)

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3. PrP genotype contributes to determining survival times of sheep with natural scrapie
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5. Follicular dendritic cells in TSE pathogenesis
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11. A crucial role for B cells in neuroinvasive scrapie
12. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro
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14. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice
15. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells
16. Pre-clinical detection of PrPsc in nictiting membrane lymphoid tissue of sheep
17. Detection of proteinase K-resistant prion protein and infectivity in mouse spleen by 2 weeks after scrapie agent inoculation
18. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice
19. Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication
20. CNA42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells
21. Prion replication - Once again blaming the dendritic cell
22. Immunohistochemical detection of prion in lymphoid tissues of sheep with natural scrapie