What limits immune reconstitution in HIV infection? Divergent tools converge on thymic function

AIDS

Volumn 15, Issue 14, 2001, Pages 1881-1882

  Fry, Terry J ^a   Mackall, Crystal L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

HIV; Immune reconstitution; Interleukin 7; Thymus

Indexed keywords

CELL REGENERATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREACTIVITY; PHENOTYPE; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE; THYMUS FUNCTION;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HUMANS; INTERLEUKIN-7; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0035964720     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200109280-00019     Document Type: Short Survey

References (15)

1. CD8 naive T cell counts decrease progressively in HIV-infected adults
2. Age, thymopoiesis and CD4+ T lymphocyte regeneration after intensive chemotherapy
3. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
4. Changes in thymic function with age and during the treatment of HIV infection
5. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
6. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies
7. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
8. Factors influencing T-cell turnover in HIV-1-seropositive patients
9. Constraints on CD4 recovery post chemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
10. Analysis of the human thymic perivascular space during aging
11. 11-Color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity
12. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
13. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV0-uninfected individuals
14. Poor CD4+ T-cell restoration after suppression of HIV-1 replication may reflect lower thymic function
15. A potential role for interleukin-7 in T-cell homeostasis