Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients

Transplantation

Volumn 72, Issue 4, 2001, Pages 587-597

  Cho, Clifford S ^a   Burkly, Linda C ^b   Fechner Jr , John H ^a   Kirk, Allan D ^c   Oberley, Terry D ^a   Dong, Yinchen ^a   Brunner, Kevin G ^a   Peters, David ^a   Tenhoor, Christopher N ^b   Nadeau, Kari ^b   Yagci, Gokhan ^a   Ishido, Nobuhiro ^a   Schultz, Jacqueline M ^a   Tsuchida, Masahiro ^a   Hamawy, Majed M ^a   Knechtle, Stuart J ^a  

^a University of Wisconsin Health   (United States)

^b BIOGEN   (United States)

^c NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOSPORIN A; GLYCOPROTEIN GP 39; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HU5C8; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; UNCLASSIFIED DRUG;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; GRAFT SURVIVAL; HISTOLOGY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY;

EID: 0035959443     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200108270-00006     Document Type: Article

References (20)

1. CD40:CD154 interactions and allograft rejection
2. CD40 ligation prevents neonatal induction of transplantation tolerance
3. CD40-CD40L interactions play a critical role during allograft rejection
4. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
5. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
6. Costimulation pathways in host immune responses to allogeneic hepatocytes
7. Prolongation of primate cardiac allograft survival by treatment with anti-CD40 ligand (CD154) antibody
8. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
9. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
10. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154
11. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
12. Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment
13. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
14. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
15. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFκB: Implications for tolerance induction
16. Identification of novel Mamu-DRB alleles using DGGE and direct sequencing
17. FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts
18. Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9
19. Primate renal transplants using immunotoxin
20. Compromised kidney graft rejection response in Vervet monkeys after withdrawal of immunosuppressants tacrolimus and sirolimus