The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix

Journal of Molecular Biology

Volumn 284, Issue 2, 1998, Pages 477-488

  Olsen, Helle B ^a   Ludvigsen, Svend ^a   Kaarsholm, Niels C ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Insulin A chain; Insulin mutant; Insulin receptor affinity; NMR; Solution structure

Indexed keywords

DRUG CARRIER; INSULIN; INSULIN RECEPTOR; MUTANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

EID: 0032573528     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2175     Document Type: Article

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