Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice

Cancer Letters

Volumn 166, Issue 2, 2001, Pages 215-221

  Schumacher, Udo ^a   Adam, Elizabeth ^b   Feldhaus, Susanne ^a   Katoh, Marcus ^a   Lane, David P ^c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Apoptosis; Cell differentiation; Chemotherapy; Mdm2; p53; scid mouse

Indexed keywords

FLUOROURACIL; PROTEIN MDM2; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CELL DIFFERENTIATION; COLON CARCINOMA; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNET RING CARCINOMA; UNDIFFERENTIATED CARCINOMA;

ANIMALS; CARCINOMA, SIGNET RING CELL; CELL DIFFERENTIATION; CELL NUCLEUS; COLONIC NEOPLASMS; CYTOPLASM; HT29 CELLS; HUMANS; MICE; MICE, SCID; MUTATION; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035954124     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00395-0     Document Type: Article

References (22)

1. The war on cancer
2. Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: Intratumoral spread and distribution effects
3. Will a twist of viral fate lead to a new cancer treatment
4. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
5. Use of clinically relevant human/SCID mouse models in metastases research
6. Lectin histochemical HPA binding pattern of human breast and colon cancers is associated with metastases formation in SCID mice
7. Differential expression of carbohydrate residues in human breast and colon cancer cell lines grown in vitro and in vivo in SCID mice
8. The action of 5-fluorouracil on human HT29 colon cancer cells grown in SCID mice: Mitosis, apoptosis and cell differentiation
9. Mdm2 promotes the rapid degradation of p53
10. Regulation of the p53 protein by the MDM2 oncoprotein - Thirty-eighth G.H.A. Clowes Memorial Award Lecture
11. A standardized method of using nude mice for the in vivo screening of antitumour drugs for human tumours
12. Combination of the peroxidase anti-peroxidase (PAP) and avidin-biotin-peroxidase complex (ABC)-techniques: An amplification alternative in immunocytochemical staining
13. Simultaneous ultrastructural demonstration of retrogradely transported horseradish peroxidase and choline acetyltransferase immunoreactivity
14. p53 mutations in colorectal cancer
15. Immunohistochemical demonstration of p53 protein in colorectal adenomas and adenocarcinomas. Reliable application of the heat-induced antigen retrieval method to formalin-fixed, paraffin-embedded material
16. Tumors as caricatures of the process of tissue renewal: Prospects for therapy by directing differentiation
17. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
18. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
19. Induction of Mdm2 and enhancement of cell survival by bFGF
20. p53 ubiquitination and degradation in nonstressed cells
21. Signalling to p53: Breaking the MDM2-p53 circuit
22. Regulation of p53 stability and activity in response to genotoxic stress