Solid-phase synthesis of 1,3-disubstituted 2-thioxoquinazoline-4-ones using SNAr reaction

Tetrahedron Letters

Volumn 42, Issue 9, 2001, Pages 1749-1752

  Makino, Shingo ^a   Nakanishi, Eiji ^a   Tsuji, Takashi ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

2 thioxoquinazoline 4 one; SNAr reaction; Solid phase synthesis

Indexed keywords

2 FLUORO 5 NITROBENZOYL AMIDE DERIVATIVE; 2 METHOXYCARBONYLPHENYLISOTHIOCYANATE; 2 THIOXOQUINAZOLINE 4 ONE DERIVATIVE; AMIDE; HALIDE; IMIDAZOLE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIOCARBONYLDIIMIDAZOLE; THIOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; COMBINATORIAL CHEMISTRY; CYCLIZATION; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0035951944     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)00008-9     Document Type: Article

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18. +.
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20. SynPhase™ Lanterns are available from Mimotopes (Clayton, Victoria, Australia). The type of lantern used in this communication was SP-PS-D-HMP (long chain hydroxymethyl phenoxy linker), loading 35 μmol/lantern.
21. Disposable polypropylene/polyethylene syringes are available from Aldrich (Milwaukee, WI).
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23. Genevac HT-8 available from Genevac Limited (Farthing Road, Ipswich, IP1 5AP, UK).