In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466

Brain Research

Volumn 890, Issue 1, 2001, Pages 66-77

  Lees, Gordon J ^a   Leong, Wing ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

2,3 Benzodiazepines; AMPA; Anticonvulsant; GYKI 52466; Hippocampus; Kainic acid; Neuronal cell death; Non NMDA glutamate receptor antagonist

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; KAINIC ACID; NEUROPROTECTIVE AGENT;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ELECTROENCEPHALOGRAM; EPILEPSY; HIPPOCAMPUS; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; CELL DEATH; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; KAINIC ACID; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SEIZURES;

EID: 0035951655     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03080-8     Document Type: Article

References (38)

1. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
2. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles
3. Neuropharmacology of AMPA and kainate receptors
4. AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death
5. 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: Novel AMPA receptor antagonists
6. 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: A new class of AMPA receptor antagonists
7. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord
8. GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells
9. Allosteric regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines
10. The effect of the non-NMDA receptor antagonists GYKI 52466 and NBQX and the competitive NMDA receptor antagonist d-CPPene on the development of amygdala kindling and on amygdala-kindled seizures
11. Synaptic activation of kainate receptors on hippocampal interneurons
12. A receptor gene expression in rat hippocampus following kainate-induced status epilepticus
13. Mechanisms of AMPA neurotoxicity in rat brain slices
14. Pharmacology of AMPA antagonists and their role in neuroprotection
15. AMPA receptor-mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization
16. Cyclothiazide and GYKI52466 modulate AMPA receptor-mediated apoptosis in cortical neuronal cultures
17. GYKI 53665, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity
18. Effects of anaesthetics, anticonvulsants and glutamate antagonists on kainic acid-induced local and distal neuronal loss
19. Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders
20. The non-NMDA glutamate antagonist NBQX blocks the local hippocampal toxicity of kainic acid, but not the diffuse extrahippocampal damage
21. Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally
22. Synergy between diazepam and NBQX in preventing neuronal death caused by non-NMDA agonists
23. Glutamate receptors of the kainate type and synaptic transmission
24. The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents
25. A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: Pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy
26. GYKI 52466 protects against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures
27. The organization of the projection from the cerebral cortex to the striatum in the rat
28. Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus
29. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
30. Decahydroisoquinolines: Novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia
31. Drug solubilizers to aid pharmacologists: Amorphous cyclodextrin derivatives
32. Kainate receptor modulation of GABA release involves a metabotropic function
33. On the relation between seizures and brain lesions after intracerebroventricular kainic acid
34. The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy
35. The synaptic activation of kainate receptors
36. The functional study of kainate receptors-hopes and doubts
37. Activation and desensitization of hippocampal kainate receptors