Interplay of pituitary adenylate cyclase-activating polypeptide with a silencer element to regulate the upstream promoter of the human gonadotropin-releasing hormone receptor gene

Molecular and Cellular Endocrinology

Volumn 176, Issue 1-2, 2001, Pages 135-144

  Ngan, Elly S W ^a   Leung, Peter C K ^b   Chow, Billy K C ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

cAMP; Gene regulation; Gonadotrope; Human GnRH receptor; Human reproduction; PACAP; Promoter; Silencer

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; CYCLIC AMP; FORSKOLIN; GONADORELIN RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; GENE CONTROL; GENETIC TRANSFECTION; MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REPRODUCTION; SILENCER GENE;

BASE SEQUENCE; BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; DNA; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FORSKOLIN; GENE SILENCING; GENES, REPORTER; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, LHRH; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035947399     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00402-6     Document Type: Article

References (34)

1. Arimura A. Pituitary adenylate cyclase activating polypeptide (PACAP): discovery, and current status of research. Regul. Pept. 37:1992;287-303.
2. Attardi B., Winters S.J. Transcriptional regulation of the glycoprotein hormone a-subunit gene by pituitary adenylate cyclase-activating polypeptide (PACAP) in αT3-1 cells. Mol. Cell. Endocrinol. 137:1998;97-107.
3. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhi K. Current Protocols in Molecular Biology. 1987;Wiley, New York.
4. Chow B.K.C., Ting V., Tufaro F., MacGillivray R.T.A. Characterization of a novel liver-specific enhancer in the human prothrombin gene. J. Biol. Chem. 266:1991;18927-18933.
5. Culler M.D., Paschall C.S. Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates the gonadotropin-releasing activity of luteinizing hormone-releasing hormone. Endocrinology. 129:1991;2260-2262.
6. Duval D.L., Ellsworth S., Clay C.M. Is gonadotrope expression of the gonadotropin releasing hormone receptor gene mediated by autocrine/paracrine stimulation of an activin response element? Endocrinology. 140:1999;1949-1952.
7. Evans J.J. Modulation of gonadotropin levels by peptides acting at the anterior pituitary gland. Endocr. Rev. 20:1999;46-67.
8. Gottschall P.E., Tatsuno I., Arimura A. Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase activating polypeptide. Endocrinology. 127:1990;272-277.
9. Gras S., Hannibal J., Fahrenkrug J. Pituitary adenylate cyclase-activating polypeptide is an auto/paracrine stimulator of acute progesterone accumulation and subsequent luteinization in cultured periovulatory granulosa/lutein cells. Endocrinology. 140:1999;2199-2205.
10. Heindel J.J., Sneeden J., Powell C.J., Davis B., Culler M.D. A novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, regulates the function of rat granulosa cells in vitro. Biol. Reprod. 54:1996;523-530.
11. Horn F., Bilezikjian L.M., Perrin M.H., Bosma M.M., Windle J.J., Huber K.S., Blount A.L., Hille B., Vale W., Mellon P.L. Intracellular responses to gonadotropin-releasing hormone in a clonal cell line of the gonadotrope lineage. Mol. Endocrinol. 5:1991;347-355.
12. Houslay M.D. 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. Eur. J. Biochem. 195:1990;9-27.
13. Kotani E., Usuki S., Kubo T. Rat corpus luteum expresses both PACAP and PACAP type 1A receptor mRNAs. Peptides. 18:1997;1453-1455.
14. Lee K.A.W., Bindereif A., Green M.R. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Techn. 5:1988;22-31.
15. Lin X.W., Conn M. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH and cyclic adenosine monophosphate. Endocrinology. 139:1998;3896-3902.
16. Lin X.W., Conn P.M. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways. Endocrinology. 140:1999;358-364.
17. McArdle C.A., Poch A., Schomerus E., Kratzmeier M. Pituitary adenylate cyclase-activating polypeptide effects in pituitary cells: modulation by gonadotropin-releasing hormone in αT3-1 cells. Endocrinology. 134:1994;2599-2605.
18. Motulsky H.J., Searle P. GraphRad Prism User's Guide, Version 2. 1995;GraphPad Software, San Diego, CA.
19. Ngan E.S.W., Cheng P.K.W., Leung P.C.K., Chow B.K.C. Steroidogenic factor-1 interacts with a gonadotrope-specific element within the first exon of the human gonadotropin-releasing hormone receptor gene to mediate gonadotrope-specific expression. Endocrinology. 140:1999;2452-2462.
20. Ngan E.S.W., Leung P.K.C., Chow B.K.C. Identification of an upstream promoter in the human gonadotropin releasing hormone receptor gene. Biochem. Biophys. Res. Commun. 270:2000;766-772.
21. Norwitz E.R., Cardona G.R., Jeong K.H., Chin W.W. Identification and characterization of the gonadotropin-releasing hormone response elements in the mouse gonadotropin-releasing hormone receptor gene. J. Biol. Chem. 274:1999;867-880.
22. Ogi K., Miyamoto Y., Masuda Y., Habta Y., Hosoya M., Ohtaki T., Masuo Y., Onda H., Fujino M. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. Biochem. Biophys. Res. Commun. 196:1993;1511-1521.
23. Rawlings S.R., Hezareh M. Pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland. Endocr. Rev. 17:1996;4-29.
24. Romanelli F., Fillo S., Isidori A., Conte D. Pituitary adenylate cyclase-activating polypeptide regulates rat Leydig cell function in vitro. Neuropeptides. 31:1997;311-317.
25. Shivers B.D., Gorcs T.J., Gottschall P.E., Arimura A. Two high affinity binding sites for pituitary adenylate cyclase activating polypeptide have different tissue distributions. Endocrinology. 128:1991;3055-3065.
26. Shuto Y., Somogyvari-vigh A., Shioda S., Onda H., Arimura A. Effect of hypophysectomy on pituitary adenylate cyclase-activating polypeptide gene expression in rat testis. Peptides. 16:1995;1039-1044.
27. Stojulkovic S.S., Reinhart J., Catt K.J. Gonadotropin-releasing hormone receptors: structure and signal transduction pathways. Endocr. Rev. 15:1994;462-499.
28. Tsujii T., Ishizaka K., Winter S.J. Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acid in perfused rat pituitary cells. Endocrinology. 135:1994;826-833.
29. Wei Y., Mojsov S. Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: Implications for their role in human physiology. J. Neuroendocrinol. 8:1996;811-817.
30. White B.R., Duval D.L., Mulvaney J.M., Roberson M.S., Clay C.M. Homologous regulation of the gonadotropin-releasing hormone receptor gene is partially mediated by protein kinase C activation of an activator protein-1 element. Mol. Endocrinol. 13:1999;566-577.
31. Wieczorek E., Lin Z., Perkins B., Law D.J., Merchant J.L., Zehner A.E. The zinc finger repressor, ZBP-89, binds to the silencer element of the human vimentin gene and complexes with the transcriptional activator, Sp1. J. Biol. Chem. 275:2000;12879-12888.
32. Windle J.J., Weiner R.I., Mellon P.L. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4:1990;597-603.
33. Young L.S., Naik S.I., Clayton R.N. Adenosine 3′, 5′-monophosphate derivatives increase gonadotropin-releasing hormone receptors in cultured pituitary cells. Endocrinology. 114:1984;2114-2122.
34. Zhong Y., Kasson B.G. Pituitary adenylate cyclase-activating polypeptide stimulates steroidogenesis and adenosine 3′, 5′-monophosphate accumulation in cultured rat granulosa cells. Endocrinology. 135:1994;207-213.