Pituitary adenylate cyclase-activating polypeptide regulates rat Leydig cell function in vitro

Neuropeptides

Volumn 31, Issue 4, 1997, Pages 311-317

  Romanelli, F ^a,b   Fillo, S ^a   Isidori, A ^a   Conte, D ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHORIONIC GONADOTROPIN; CYCLIC AMP; INDOMETACIN; PHOSPHATIDYLINOSITOL; POLYPEPTIDE; PROSTAGLANDIN E2; TESTOSTERONE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; HORMONE RESPONSE; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; STEROIDOGENESIS;

ANIMALIA;

EID: 0030826718     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4179(97)90064-0     Document Type: Article

References (37)

1. Miyata A, Arimura A, Dahl R R et al. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 1989; 164: 567-574.
2. Miyata A, Jiang L, Dahl R D et al. Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase-activating polypeptide with 38 residues (PACAP-38). Biochem Biophys Res Commun 1990; 170: 643-648.
3. i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism. J Biol Chem 1994; 269: 5680-5686.
4. Rawlings S R. PACAP, PACAP receptors, and intracellular signalling. Mol Cell Endocrinol 1994; 101: C5-C9.
5. Arimura A, Somogyvàri-Vigh A, Miyata A, Mizuno K, Coy D H, Kitada C. Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology 1991; 129: 2787-2789.
6. Arimura A. Pituitary adenylate cyclase-activating polypeptide (PACAP): discovery and current status of research. Regul Pept 1992; 37: 287-303.
7. Culler M D, Paschall C S. Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates the gonadotropin-releasing activity of luteinizing hormone-releasing hormone. Endocrinology 1992; 129: 2260-2262.
8. Hart G R, Gowing H, Burrin J M. Effects of a novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, on pituitary hormone release in rats. J Endocrinol 1992; 134: 33-41.
9. McArdle C A, Schomerus P E, Kratzmeier M. Pituitary adenylate cyclase-activating polypeptide effects in pituitary cells: modulation by gonadotropin-releasing hormone in αT3-1 cells. Endocrinology 1994; 134: 2599-2605.
10. Tsujii T, Ishizaka K, Winters S J. Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acid in perifused rat pituitary cells. Endocrinology 1994; 135: 826-833.
11. Andreis P G, Malendowicz L K, Belloni A S, Nussdorfer G G. Effects of pituitary adenylate-cyclase activating peptide (PACAP) on the rat adrenal secretory activity: preliminary in vitro studies. Life Sci 1995; 56: 135-142.
12. Neri G, Andreis P G, Prayer-Galetti T, Rossi G P, Malendowicz L K, Nussdorfer G G. Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines. J Clin Endocrinol Metab 1996; 81: 169-173.
13. Heindel JJ, Sneeden J, Powell C J, Davis B, Culler M D. A novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, regulates the function of rat granulosa cells in vitro. Biol Reprod 1996; 54: 523-530.
14. Shivers B D, Gorcs T J, Gottschall P E, Arimura A. Two high affinity binding sites for pituitary adenylate cyclase-activating polypeptide have different tissue distributions. Endocrinology 1991; 128: 3055-3065.
15. Harmar T, Lutz E. Multiple receptor for PACAP and VIP. Trends Pharmacol Sci 1994; 15: 97-99.
16. Christope J. Type I receptors for PACAP (a neuropeptide even more important than VIP?). Biochem Biophys Acta 1993; 1154: 183-199.
17. Arimura A. Receptors for pituitary adenylate cyclase-activating peptide. Comparison with vasoactive intestinal peptide receptors. Trends Endocrinol Metab 1992; 3: 288-294.
18. Hannibal J, Fahrenkrug J. Expression of pituitary adenylate cyclase activating polypeptide (PACAP) gene by rat spermatogenic cells. Regul Pept 1995; 55: 111-115.
19. Krempels K, Usdin T B, Harta G, Mezey E. PACAP acts through VIP type 2 receptors in the rat testis. Neuropeptides 1995; 29: 315-320.
20. Shuto Y, Somogyvàri-Vigh A, Shioda S, Onda H, Arimura A. Effect of hypophysectomy on pituitary adenylate cyclase-activating polypeptide gene expression in the rat testis. Peptides 1995; 16: 1039-1044.
21. West A P, McKinnell C, Sharpe R M, Saunders P T K. Pituitary adenylate cyclase-activating polypeptide can regulate testicular germ cell protein synthesis in vitro. J Endocrinol 1995; 144: 215-223.
22. Kononen J, Paavola M, Penttila T L, Parvinen M, Pelto-Huikko M. Stage-specific expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in the rat seminiferous tubules. Endocrinology 1994; 135: 2291-2295.
23. Shioda S, Legradi G, Leung W, Nakajo S, Nakaya K, Arimura A. Localization of pituitary adenylate cyclase-activating polypeptide and its messenger ribonucleic acid in the rat testis by light and electron microscopic immunocytochemistry and in situ hybridization. Endocrinology 1994; 135: 818-825.
24. Hurley J D, Gardiner J V, Jones P M, Bloom S R. Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis. Endocrinology 1995; 136: 550-557.
25. Heindel J J, Powell J P, Paschall C S, Arimura A, Culler M D. A novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, modulates Sertoli cell function in vitro. Biol Reprod 1992; 47: 800-806.
26. Romanelli F, Valenca M, Conte D, Isidori A, Negro-Vilar A. Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. J Endocrinol Invest 1995; 18: 186-193.
27. Alfred L F, Cooke B A. The effect of the cell damage on the density and steroidogenic capacity of rat testis Leydig cells, using an NADH exclusion test for determination of viability. J Steroid Biochem 1983; 18: 411-416.
28. Conte D, Questino P, Fillo S, Nordio M, Isidori A, Romanelli F. Endothelin stimulates testosterone secretion by rat Leydig cells. J Endocrinol 1993; 136: R1-R4.
29. Zar H. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice Hall, 1984.
30. Dufau M L, Tsuruhara T, Horner K A, Podesta E, Catt K J. Evidence for an intermediate role of cyclic AMP and protein kinase during gonadotropin action on steroidogenesis. Proc Natl Acad Sci USA 1977; 74: 3419-3423.
31. Naor Z. Arachidonic acid a second messenger in signal transduction? Mol Cell Endocrinol 1991; 80: C181-C186.
32. McArdle C A, Caunis R. GnRH and PACAP action in gonadotropes. Cross-talk between phosphoinositase C and adenylyl cyclase mediated signaling pathways. Trends Endocrinol Metab 1996; 7: 168-173.
33. Ciampani T, Fabbri A, Isidori A, Dufau M L. Growth hormone-releasing hormone is produced by rat Leydig cell in culture and acts as a positive regulator of Leydig cell function. Endocrinology 1992; 131: 2785-2792.
34. Kasson G B, Aaron P L, Hsueh J W. Vasoactive intestinal peptide stimulates androgen biosynthesis by cultured neonatal testicular cells. Mol Cell Endocrinol 1986; 48: 21-26.
35. Rawlings S R, Hezareh M. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal peptide receptors: actions on the anterior pituitary gland. Endocr Rev 1996; 17: 4-28.
36. Heindel J J, Sneeden J, Powell C J, Davis B, Culler M D. A novel hypothalamic peptide, pituitary adenylate cyclase-activating peptide, regulates the function of rat granulosa cells in vitro. Biol Reprod 1996; 54: 523-530.
37. Sprengler D, Waeber C, Pantaloni C et al. Differential signal transduction by five splice variants of the PACAP receptor. Nature 1993; 365: 170-175.