Genetic and Molecular Characterization of Skb15, a Highly Conserved Inhibitor of the Fission Yeast PAK, Shk1

Molecular Cell

Volumn 7, Issue 5, 2001, Pages 1095-1101

  Kim, HyeWon ^a   Yang, Peirong ^a   Qyang, Yibing ^a   Lai, Hong ^a   Du, Hongyan ^a   Henkel, Jenny S ^a   Kumar, Kiran ^a   Bao, Shilai ^a   Liu, Mingyao ^b   Marcus, Stevan ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL ENZYME; M PROTEIN; PROTEIN P21 ACTIVATED KINASE; SHK1 KINASE; SKB 15 PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; BIOGENESIS; CELL CYCLE; CELL KINETICS; CONTROLLED STUDY; DEREGULATION; EVOLUTION; MACHINE; MICROTUBULE; MUTATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SCHIZOSACCHAROMYCES POMBE;

EID: 0035947081     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00248-9     Document Type: Article

References (31)

1. Direct binding and In vivo regulation of the fission yeast p21- activated kinase shk1 by the SH3 domain protein scd2
2. Cooperative interaction of S. pombe proteins required for mating and morphogenesis
3. PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis
4. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast
5. p21-activated protein kinase: A crucial component of morphological signaling?
6. A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos
7. Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation
8. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe
9. Relationships between the central spindle and the contractile ring during cytokinesis in animal cells
10. Negative regulation of mitosis in fission yeast by the shk1interacting protein skb1 and its human homolog, Skb1Hs
11. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog
12. The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein
13. CYK-4: A rho family gtpase activating protein (Gap) required for central spindle formation and cytokinesis
14. Controlling septation in fission yeast: Finding the middle, and timing it right
15. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe
16. nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine
17. Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe
18. Involvement of ras in sexual differentiation but not in growth control in fission yeast
19. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating
20. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity
21. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
22. Characterization of Pak2p, a pleckstrin homology domain-containing, p21- activated protein kinase from fission yeast
23. Emerging from the Pak - the P21-activated protein kinase family
24. Genetic evidence for pak1 autoinhibition and its release by cdc42
25. Complex formation between RAS and RAF and other protein kinases
26. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
27. Mammalian Ras interacts directly with the serine/threonine kinase Raf
28. Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast
29. Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5