In ovo chronic neurosteroid treatment affects the function and allosteric interactions of GABAA receptor modulatory sites

Brain Research

Volumn 902, Issue 1, 2001, Pages 74-81

  Pignataro, Leonardo ^a   Fiszer de Plazas, Sara ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Central nervous system (CNS); Chloride channel; Development; Epipregnanolone chronic treatment; GABAA receptor; Uncoupling

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5BETA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; CHLORIDE ION; DIAZEPAM; FLUNITRAZEPAM; LIGAND; NEUROSTEROID; PENTOBARBITAL; TRITIUM;

ALLOSTERISM; ARTICLE; BRAIN DEVELOPMENT; CHICK EMBRYO; CHLORIDE TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG EFFECT; DRUG EXPOSURE; DRUG RECEPTOR BINDING; EMBRYO; EMBRYO DEVELOPMENT; LONG TERM EXPOSURE; NONHUMAN; OPTIC LOBE; PRIORITY JOURNAL; PROTEIN CONTENT; TREATMENT OUTCOME;

ALLOSTERIC REGULATION; ANIMALS; CHICK EMBRYO; CHLORIDE CHANNELS; CHLORIDES; FLUNITRAZEPAM; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; ION TRANSPORT; NERVE TISSUE PROTEINS; OPTIC LOBE; PREGNANOLONE; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION;

EID: 0035947055     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02353-8     Document Type: Article

References (35)

1. Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels
2. 3H]diazepam binding
3. Amino acid transmitters and local circuitry in optic tectum
4. Gamma-aminobutyric acid (GABA) receptor binding in mammalian retina
5. Effect of diazepam on the low affinity GABA binding sites at different developmental stages of the chick optic lobe
6. Pentobarbital modulatory effect on GABA binding sites in developing chick optic lobe
7. Development of GABA binding sites in chick embryo optic lobe: Effect of Triton X-100
8. A receptor regulation: Chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites
9. A receptor regulation: Heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, banzodiazepine, or GABA treatment in culture
10. Steroid modulation of the chloride ionophore in rat-brain: Structure-activity requirements, regional dependence and mechanism of action
11. Benzodiazepine receptor sites in the chick optic lobe: Development and pharmcological characterization
12. GABA-stimulated chloride uptake during avian CNS development: Modulation by neurosteroids
13. Sterois anaesthetics
14. Benzodizepine: Modes of action
15. A series of normal stages in the developing chick embryo
16. A receptor complex
17. Neurosteroids: Cytochrome P450scc in rat brain
18. Protein measurement with Folin phenol reagent
19. A receptor channels
20. Steroid hormones metabolites are a barbiturate-like modulators of the GABA receptor
21. A receptors
22. A receptor complex
23. A receptor complex in avian CNS
24. Neurosteroid modulation of the Benzodiazepine receptor in developing chick optic lobe
25. A receptor-complex
26. A receptors
27. Steroid and babiturate modulation of the GABA receptor
28. γ-Aminobutyric acid content and glutamate decarboxylase activities in the optic lobe of the developing chick
29. Steroid anesthetics and naturally occuring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates
30. 3H]GABA binding in developing chick optic lobe
31. Comparative modulation by 3α,5α and 3β,5β neurosteroids of GABA binding sites during avian central nervous system development
32. Neurosteroid modulation of GABA binding sites in developing avian central nervous system
33. A receptor complex in mammalian cortical neurons
34. Chronic neurosteroid treatment produced functional heterologous uncoupling at the γ-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons