The two-step model for translesion synthesis: Then and now

Mutation Research - DNA Repair

Volumn 485, Issue 1, 2001, Pages 61-67

  Bridges, B ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

"Two step" model for SOS mutagenesis; DNA polymerases, in mutagenesis; SOS repair; Translesion synthesis; UV mutagenesis

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; DNA POLYMERASE IV; DNA POLYMERASE V; GENE PRODUCT; PROTEIN UMUC; PROTEIN UMUD2; UNCLASSIFIED DRUG;

CHROMOSOME REPLICATION; CONFERENCE PAPER; DNA REPAIR; ENZYME ACTIVITY; FRAMESHIFT MUTATION; GENE CASSETTE; MOLECULAR GENETICS; MUTAGENESIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ULTRAVIOLET RADIATION;

BACTERIA; DNA DAMAGE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HISTORY, 20TH CENTURY; MODELS, GENETIC; MUTAGENESIS; SOS RESPONSE (GENETICS);

EUKARYOTA;

EID: 0035946007     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(00)00074-4     Document Type: Conference Paper

References (46)

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3. The two-step model of bacterial UV mutagenesis
4. Contribution of 3′-5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity
5. Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit of DNA poymerase III: A possible mechanism for SOS-induced targeted mutagenesis
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8. RecA-mediated cleavage activates UmuD for mutagenesis: Mechanistic relationship between transcriptional derepression and post-translational activation
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10. Mutational specificity of a proofreading defective Escherichia coli dnaQ49 mutator
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14. The antimutagenic effect of a truncated epsilon subunit of DNA polymerase III in Escherichia coli cells irradiated with UV light
15. Isolation and characterisation of mutants with deletions in dnaQ, the gene for the editing subunit of DNA poymerase III in Salmonella typhimurium
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33. Cold sensitivity induced by overproduction of UmuD, C in Escherichia coli
34. Overproduction of the beta subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coli
35. The Escherichia coli SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase
36. A phenotype for enigmatic DNA polymerase II: A pivotal role for Pol II in replication restart in UV-irradiated Escherichia coli
37. DNA polymerases and SOS mutagenesis: Can one reconcile the biochemical and genetic data?
38. Escherichia coli DNA polymerase II catalyses chromosomal and episomal DNA synthesis in vivo
39. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase ι
40. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
41. Frequency and spectrum of mutations produced by a single cis-syn T-T cyclobutane dimer in a single stranded vector
42. Substitution of mucAB or rumAB for umuD C alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis
43. Intrinsic polymerase activities of UmuD′(2)C and MucA′(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer
44. Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli. Strain specificity and mutation-prone sequences
45. Sensitization of Escherichia coli to gamma-radiation by N-ethylmaleimide