Therapeutic immune reconstitution in HIV-1-infected children is independent of their age and pretreatment immune status

AIDS

Volumn 15, Issue 17, 2001, Pages 2267-2275

  Van Rossum, Annemarie M C ^a   Scherpbier, Henriette J ^a   Van Lochem, Ellen G ^a   Pakker, Nadine G ^a   Slieker, Walentina A T ^a   Wolthers, Katja C ^a   Roos, Marijke T L ^a   Kuijpers, Jac H S A M ^a   Hooijkaas, Herbert ^a   Hartwig, Nico G ^a   Geelen, Sibyl P M ^a   Wolfs, Tom F W ^a   Lange, Joep M A ^a   Miedema, Frank ^a   De Groot, Ronald ^a   Jurriaans, S ^a   Hoetelmans, R ^a   Veerman, A J P ^a   Vossen, J M ^a   Schrander, J J P ^a   Burger, D M ^a   Weemaes, C M R ^a   Niester, H G M ^a   Osterhaus, A D M E ^a   Vulto, A G ^a   Boucher, C ^a   Rijkers, G T ^a   more..

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

CD4 T cell count; Children; Highly active antiretroviral therapy; HIV 1; Immune reconstitution

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NELFINAVIR; STAVUDINE; ZIDOVUDINE;

ADOLESCENT; ADULT; AGE; ARTICLE; CELL PROLIFERATION; CHILD; DISEASE ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOPHENOTYPING; INFANT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; AGE FACTORS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; INFANT; PROSPECTIVE STUDIES; RNA, VIRAL; VIRAL LOAD;

EID: 0035941380     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200111230-00008     Document Type: Article

References (29)

1. Clinical and immunovirologic characterization of the efficacy of stavudine, lamivudine, and indinavir in human immunodeficiency virus infection
2. Preliminary experiences with triple therapy including nelfinavir and two reverse transcriptase inhibitors in previously untreated HIV- infected children
3. Clinical and virologic response to combination treatment with indinavir, zidovudine, and lamivudine in children with human immunodeficiency virus-1 infection: A multicenter study in The Netherlands
4. Comparison of two antiretroviral triple combinations including the protease inhibitor indinavir in children infected with human immunodeficiency virus
5. Indinavir in combination with stavudine and lamivudine in HIV-infected children
6. Immunoreconstitution after ritonavir therapy in children with human immunodeficiency virus infection involves multiple lymphocyte lineages
7. Positive effects of combined antiretroviral therapy on CD4 T cell homeostasis and function in advanced HIV disease
8. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
9. Age, thymopoiesis, and CD4 T lymphocyte regeneration after intensive chemotherapy
10. Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
11. Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume
12. Distinctions between CD8 and CD4 T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy
13. Early effects of antiretroviral combination therapy on activation, apoptosis and regeneration of T cells in HIV-1-infected children and adolescents
14. Early recovery of CD4 T lymphocytes in children on highly active antiretroviral therapy
15. Immunologic and virologic responses to HAART in severely immunocompromised HIV-1-infected children
16. Immune repopulation after HAART in previously untreated HIV-1-infected children
17. Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults
18. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations
19. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements
20. Phenotypic and functional separation of memory and effector human CD8 T cells
21. CD8 naive T cell counts decrease progressively in HIV-infected adults
22. Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy
23. Whole-blood lymphocyte cultures
24. Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS
25. 1994 Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. Official authorized addenda: Human immunodeficiency virus infection codes and official guidelines for coding and reporting ICD-9-CM
26. Thymus volume correlates with the progression of vertical HIV infection
27. CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)
28. Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
29. Effect of HIV on thymic function before and after antiretroviral therapy in children