Constitutive hyperexpression of p21WAF1 in humanUu266 myeloma cells blocks the lethal signaling induced by oxidative stress but not by Fas

Biochemical and Biophysical Research Communications

Volumn 289, Issue 1, 2001, Pages 34-38

  Kyun Kim, Do ^a   Sook Cho, Eun ^a   Lee, Su Jae ^b   Um, Hong Duck ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Korea Cancer Center Hospital   (South Korea)

Author keywords

Cell death; Fas; Hydrogen peroxide; Multiple myeloma; Myeloma cells; Oxidative stress; p21; SAPK JNK

Indexed keywords

FAS ANTIGEN; PROTEIN P21;

ARTICLE; CELL DEATH; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035940978     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5928     Document Type: Article

References (27)

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3. Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis
4. Fas antigen/APO-1 (CD95) expression on myeloma cells
5. FLIP is constitutively hyperexpressed in Fas-resistant U266 myeloma cells, but is not induced by IL-6 in Fas-sensitive RPMI8226 cells
6. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
7. Overexpressed WAS1/CIP1 renders glioblastoma cells resistant to chemotherapy against 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin
8. waf1 initiated by membrane IgM engagement increases survival of B lymphoma cells
9. WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-β-D-arabinofuranosylcysteine-mediated mitochondrial dysfunction and apoptosis
10. p21 promotes ceramide-induced apoptosis and antagonizes the antideath effect of Bcl-2 in human hepatocarcinoma cells
11. Interleukin-6 overcomes p21WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-γ in multiple myeloma cells
12. Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway
13. Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite
14. Lipopolysaccharide, tumor necrosis factorα, and IL-1β prevent programmed cell death (apoptosis) in human peripheral blood monocytes
15. Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration
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27. 2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells