Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins

Developmental Brain Research

Volumn 130, Issue 1, 2001, Pages 91-98

  Stull, N D ^a   Jung, J W ^a   Iacovitti, L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Bone morphogenetic protein; Cultured striatal neuron; Differentiation; Dopaminergic phenotype; Tissue culture

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; APIGENIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; EMBRYO; ENZYME INDUCTION; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; SUPPLEMENTATION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CORPUS STRIATUM; DOPAMINE; ENZYME INHIBITORS; FEMALE; FETUS; FLAVONOIDS; IMMUNOHISTOCHEMISTRY; MICE; NEURONS; PHENOTYPE; PREGNANCY; TRANSFORMING GROWTH FACTOR BETA; TYROSINE 3-MONOOXYGENASE;

EID: 0035940287     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(01)00216-4     Document Type: Article

References (49)

1. Transient expression of tyrosine hydroxylase immunoreactivity in some neurons of the rat neocortex during postnatal development
2. Growth of a rat neuroblastoma cell line in serum-free supplemented medium
3. Ontogenetic appearance and disappearance of tyrosine hydroxylase and catecholamines in the rat embryo
4. Synergy between growth factors and neurotransmitters required for catecholamine differentiation in brain neurons
5. Multiple signaling pathways direct the initiation of tyrosine hydroxylase gene expression in cultured brain neurons
6. Protein kinase C activators work in synergy with specific growth factors to initiate tyrosine hydroxylase gene expression in striatal neurons in culture
7. Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator
8. Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons
9. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
10. Haplosufficient phenotypes in bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
11. Exposure of foetal mesencephalic cells to bone morphogenetic protein-2 enhances the survival of dopaminergic neurones in rat striatal grafts
12. Depolarization differentially regulates the effects of bone morphogenetic protein (BMP)-2, BMP-6 and activin A on sympathetic neuronal phenotype
13. Localization and actions of transforming growth factor-bets-s in the embryonic nervous system
14. Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins
15. Architecture and cell types of the adult subventricular zone: In search of the stem cells
16. Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: Changes in transcription factors binding the AP-1 site
17. Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation
18. Effects of a novel differentiation factor on the development of catecholamine traits in noncatecholamine neurons from various regions of the rat brain: Studies in tissue culture
19. A muscle-derived factor induces expression of a catecholamine phenotype in cultured rat cerebral cortex
20. Differentiation of human dopamine neurons from an embryonic carcinomal cell line
21. Neurotransmitters, KCl, and antioxidants rescue striatal neurons from apoptotic cell death in culture
22. Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro
23. Transient expression of tyrosine hydroxylase in some neurons of the developing inferior colliculus of the rat
24. Transient expression of selected catecholaminergic traits in cranial sensory and dorsal root ganglia of the embryonic rat
25. Bone morphogenetic proteins: Neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cells
26. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture
27. Expression of catecholaminergic characteristics by primary sensory neurons in the normal adult rat in vivo
28. What do BMPs do in mammals? Clues from the mouse short-ear mutation
29. Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity
30. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis
31. Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9
32. Co-expression of tyrosine hydroxylase and glutamic acid decarboxylase in dopamine differentiation factor-treated striatal neurons in culture
33. BDNF promotes differentiation of striatal neurons
34. Regulation of BMP/Dpp signaling during embryonic development
35. Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation
36. TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons
37. Regulation of cartilage and bone differentiation by bone morphogenetic proteins
38. Bone morphogenetic protein-2 promotes dissociated effects on the number and differentiation of cultured ventral mesencephalic dopaminergic neurons
39. Involvement of bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons
40. The transforming growth factor βs
41. Tyrosine hydroxylase-immunoreactive neurons in the mouse cerebral cortex during the postnatal period
42. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons
43. Sonic hedgehog and FGF8: Inadequate signals for the differentiation of a dopamine phenotype in mouse and human neurons in culture
44. Proliferation and distribution of cells that transiently express a catecholaminergic phenotype during development in mice and rats
45. Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
46. Discovery and clinical applications of bone morphogenetic proteins
47. Opposite effects of FGF and BMP-4 on embryonic blood formation: Roles of PV.1 and GATA-2
48. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
49. Induction of dopaminergic neurotransmitter phenotype in rat embryonic cerebrocortex by the synergistic action of neurotrophins and dopamine