DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats

Neuroscience Letters

Volumn 299, Issue 3, 2001, Pages 213-216

  Arai, Nobutaka ^a   Furukawa, Nobuya ^b   Miyamae, Takeaki ^b   Goshima, Yoshio ^b   Sasaki, Yukio ^b   Ohshima, Etsuo ^c   Suzuki, Fumio ^c   Fujita, Kiyohide ^b   Misu, Yoshimi ^b,d  

^a Tokyo Metropolitan Universit   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

^d Shinobu Hospital   (Japan)

Author keywords

Brain ischemia; Competitive DOPA antagonist; Delayed neuron death; DOPA cyclohexyl ester; Glutamate release; Hippocampus CA1; Neuroprotection

Indexed keywords

DOPA; DOPA CYCLOHEXYL ESTER; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; MALE; MICRODIALYSIS; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REPERFUSION;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; DIHYDROXYPHENYLALANINE; GLUTAMIC ACID; HIPPOCAMPUS; LEVODOPA; MALE; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 0035937039     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01520-8     Document Type: Article

References (16)

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4. L-DOPA cyclohexyl ester is a novel potent and relatively stable competitive antagonist against L-DOPA among several L-DOPA ester compounds in rats
5. BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis
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