Diaminoindanes as microsomal triglyceride transfer protein inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4677-4687

  Ksander, G M ^a   DeJesus, R ^a   Yuan, A ^a   Fink, C ^a   Moskal, M ^a   Carlson, E ^a   Kukkola, P ^a   Bilci, N ^a   Wallace, E ^a   Neubert, A ^a   Feldman, D ^a   Mogelesky, T ^a   Poirier, K ^a   Jeune, M ^a   Steele, R ^a   Wasvery, J ^a   Stephan, Z ^a   Cahill, E ^a   Webb, R ^a   Navarrete, A ^a   Lee, W ^a   Gibson, J ^a   Alexander, N ^a   Sharif, H ^a   Hospattankar, A ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID [2,3 DIHYDRO 5 [[[6 METHYL 4' (TRIFLUOROMETHYL)(1,1' BIPHENYL) 2 YL]CARBONYL]AMINO] 1H INDEN 2 YL]METHYL ESTER; CARRIER PROTEIN; CHOLESTEROL; DIAMINOINDANE DERIVATIVE; PROTEIN INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; APOLIPOPROTEINS B; BENZAMIDES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL; DOGS; GLYCERIDES; INDANS; INDENES; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; POSTPRANDIAL PERIOD; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035924183     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010294e     Document Type: Article

References (21)

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3. Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B containing lipoproteins from heterologous cells
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6. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
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8. Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein
9. Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B containing lipoproteins from heterologous cells
10. Secretion of apoB containing lipoproteins from HeLA cells dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability
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