The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis

Journal of Cell Biology

Volumn 154, Issue 4, 2001, Pages 857-866

  Jarousse, Nadine ^a   Kelly, Regis B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AP2 adaptor; Endocytosis; Internalization signal; Synaptic vesicle; Synaptotagmin

Indexed keywords

CD4 ANTIGEN; LYSINE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR AP 2;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CHIMERA; CHO CELL; CONTROLLED STUDY; ENDOCYTOSIS; EXOCYTOSIS; FIBROBLAST; HUMAN; HUMAN CELL; INTERNALIZATION; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT;

ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; BINDING SITES; CALCIUM-BINDING PROTEINS; CHO CELLS; CRICETINAE; ENDOCYTOSIS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PC12 CELLS; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RECOMBINANT FUSION PROTEINS; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

ANIMALIA;

EID: 0035921422     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103040     Document Type: Article

References (56)

1. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes
2. A novel seizure-induced synaptotagmin gene identified by differential display
3. Di-leucine signals mediate targeting of tyrosinase and synaptotagmin to synaptic-like microvesicles within PC12 cells
4. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization
5. Synaptotagmin: A calcium sensor on the synaptic vesicle surface
6. 2+-binding loop of synaptotagmin with lipid bilayers
7. Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain
8. 2+-triggered dimerization
9. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
10. Reconstitution of synaptic vesicle biogenesis from PC12 cell membranes
11. 2+ and assembly with the core SNARE complex onto membranes
12. 2+/phospholipid binding
13. 2+ sensing module essential for exocytosis
14. The effect on synaptic physiology of synaptotagmin mutations in Drosophila
15. Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers
16. The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts
17. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
18. Synaptotagmin I functions as a calcium regulator of release probability
19. Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)
20. Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain
21. Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal
22. 2+ sensor for transmitter release at a central synapse
23. 2+-dependent binding of synaptotagmin to SNARE complexes
24. Role of Drosophila α-adaptin in presynaptic vesicle recycling
25. Endocytosis of VAMP is facilitated by a synaptic vesicle targeting signal
26. AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs
27. Dual interaction of synaptotagmin with mu2- and α-adaptin facilitates clathrin-coated pit nucleation
28. Endocytotic mechanisms in synapses
29. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
30. Adaptors for clathrin-mediated traffic
31. Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
32. 2+-dependent and -independent activities of neural and non-neural synaptotagmins
33. Synaptophysin is sorted from endocytotic markers in neuroendocrine PC12 cells but not transfected fibroblasts
34. 2+ activated neurotransmitter release
35. Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants
36. 2+-triggered fusion and recycling of synaptic vesicles in vivo
37. 2+-dependent exocytosis of lysosomes in fibroblasts
38. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells
39. Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue
40. Endocytosis and molecular sorting
41. Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity
42. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
43. A structural explanation for the recognition of tyrosine-based endocytotic signals
44. Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells
45. Domain structure of synaptotagmin (p65)
46. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
47. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway
48. Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin
49. The endocytic machinery in nerve terminals surrounds sites of exocytosis
50. Synaptotagmins: C2-domain proteins that regulate membrane traffic
51. 2+-dependent properties of the first and second C2-domains of synaptotagmin I
52. Synaptotagmin 13: Structure and expression of a novel synaptotagmin
53. 2+ binding
54. Synaptotagmin regulation of coated pit assembly
55. An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface
56. Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling