Transcriptional cascades during spermatogenesis: Pivotal role of CREM and ACT

Molecular and Cellular Endocrinology

Volumn 179, Issue 1-2, 2001, Pages 17-23

  Fimia, Gian Maria ^a   Morlon, Aurore ^a   Macho, Betina ^a   De Cesare, Dario ^a   Sassone Corsi, Paolo ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

ACT; CREM; Spermatogenesis; Transcriptional cascades

Indexed keywords

ACTIVATOR OF CREM IN TESTIS; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; CELL DIFFERENTIATION; CYCLIC AMP RESPONSIVE ELEMENT; GENE CONTROL; GENE EXPRESSION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GERM CELL; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SPERMATOGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MALE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOZOA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0035919211     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00463-4     Document Type: Article

References (38)

1. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
2. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
3. Phosphorylated CREB binds specifically to the nuclear protein CBP
4. LIM domains: multiple roles as adapters and functional modifiers in protein interactions
5. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene
6. Signaling routes to CREM and CREB: plasticity in transcriptional activation
7. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression
8. Induction of CREM activator proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation
9. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
10. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex
11. CBP-independent activation of CREM and CREB by the LIM-only protein ACT
12. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM
13. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
14. Developmental switch of CREM function during spermatogenesis: from antagonist to activator
15. Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
16. Rhythmic transcription: the molecular basis of circadian melatonin synthesis
17. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
18. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
19. The Sertoli-germ cell communication network in mammals
20. Identification of a functional cyclic adenosine 3′, 5′-monophosphate response element in the 5′-flanking region of the gene for transition protein 1 (TP1), a basic chromosomal protein of mammalian spermatids
21. Histone acetylases and deacetylases in cell proliferation
22. Nuclear protein CBP is a coactivator for the transcription factor CREB
23. The functional versatility of CREM is determined by its modular structure
24. Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
25. Transcriptional regulation by cyclic AMP
26. RNA helicase A mediates association of CBP with RNA polymerase II
27. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice
28. cAMP/CREM-dependent regulation of cholesterogenic lanosterol 14-alpha demethylase (CYP51) in spermatids
29. Transcription factors responsive to cAMP
30. Transcriptional checkpoints determining the fate of male germ cells
31. CREM: a master-switch governing male germ cell differentiation and apoptosis
32. CREB: a calcium-regulated transcription factor phosphorylated by calmodulin-dependent kinases
33. The p300/CBP family: integrating signals with transcription factors and chromatin
34. CREB and memory
35. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
36. Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene
37. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
38. cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription