Regulating expression and function of G-protien-linked receptors

Progress in Neurobiology

Volumn 48, Issue 6, 1996, Pages 555-568

  Karoor, Vijaya ^a   Shih, Meiling ^a   Tholanikunnel, Baby ^a   Malbon, Craig C ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; NEUROTRANSMITTER RECEPTOR; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVIEW;

ANIMALS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0029967397     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/0301-0082(96)00004-4     Document Type: Review

References (134)

1. Alberta, J. A., Rundell, K. and Stiles, C. D. (1994) Identification of an activity that interacts with the 3′UTR of c-myc mRNA and the role of its target sequences in mediating rapid mRNA degradation. J. Biol. Chem. 269, 4532-4538.
2. Baeyens, D. A. and Cornell, L. E. (1993) Transcriptional and posttranscriptional regulation of hepatic beta 2-adrenergic receptor gene expression during development. J. Cell Physiol. 157, 70-76.
3. Baeyens, D. A. and Cornett, L. E. (1995) Association of hepatic beta 2-adrenergic receptor gene transcript destabilization during postnatal development in the Sprague-Dawley rat with a M(r) 85,000 protein that binds selectively to the beta 2-adrenergic receptor mRNA 3′-untranslated region. J. Cell Physiol. 163, 305-311.
4. Bahouth, S. W. (1991) Thyroid hormones transcriptionally regulate the beta 1-adrenergic receptor gene in cultured ventricular myocytes. J. Biol. Chem. 266, 15863-15869.
5. Bahouth, S. and Malbon, C. C. (1994) Genetic (transcriptional and post-transcriptional) regulation of G-protein-linked receptor expression. In: Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplification, pp. 99-112. Eds D. R. Sibley and M. D. Houslay. John Wiley and Sons, West Sussex, U.K.,
6. 1-adrenergic receptor gene. J. Biol. Chem., submitted.
7. Baltensperger, K., Karoor, V., Czech, M. P., Ruoho, A. and Malbon, C. C. (1996) The β-adrenergic receptor is a substrate for the insulin receptor kinase. J. Biol. Chem. 271, 1061-1064.
8. Benovic, J. L., DeBlasi, A., Stone, W. C., Caron, M. G. and Lefkowitz, R. J. (1989) β-adrenergic receptor kinase: primary structure delineates a multigene family. Science 246, 235-246.
9. Benovic, J. L., Onorato, J. J., Arriza, J. L., Stone, W. C., Lohse, M., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Caron, M. G. and Lefkowitz, R. J. (1991) Cloning, expression, and chromosomal localization of β-adrenergic receptor kinase 2. J. Biol. Chem. 266, 14939-14946.
10. 1 2, in vitro by a protein capable of binding to a coding region stability determinant. Genes & Devel. 6, 642-654.
11. Berridge, M. J. and Irvine, R. F. (1989) Inositol phosphates and cell signalling. Nature 341, 197-205.
12. Birnbaumer, L., Abramowitz, J. and Brown, A. M. (1990) Receptor-effector coupling by G-proteins. Biochem. Biophys. Acta 1031, 163-224.
13. Bohjanen, P. R., Petryniak, B., June, C. H., Thompson, C. B. and Lindsten, T. (1992) AU RNA-binding factors differ in their binding specificities and affinities. J. Biol. Chem. 267, 6302-6309.
14. Bohjanen, P. R., Petryniak, B., June, C. H., Thompson, C. B. and Lindsten, T. (1994) An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′UTR of mRNA. Molec. cell. Biol. 11, 3288-3295.
15. Bohm, M. and Lohse, M. J. (1994) Quantification of beta-adrenoceptors and beta-adrenoceptor kinase on protein and mRNA levels in heart failure. Eur. Heart J. 15, 30-34.
16. Bonnieu, A., Roux, P., Marty, L., Jeanteur, Ph. and Piechaczyk, M. (1990) AUUUA motifs are indespensable for rapid degradation of the mouse c-myc RNA. Oncogene 5, 1585-1588.
17. 2-adrenergic receptor: phosphorylation and regulation of mRNA level. J. Biol. Chem. 264, 16786-16792.
18. Brass, L. F. (1992) Homologous desensitization of HEL cell thrombin receptors distinguishes roles for proteolysis and phosphorylation. J. Biol. Chem. 267, 6044-6050.
19. Brewer, G. (1991) An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Molec. cell. Biol. 11, 2460-2466.
20. Burd, C. G., Matunis, E. L. and Dreyfuss, G. (1991) The multiple RNA-binding domains of the mRNA polyA-binding protein have different binding activities. Molec. cell. Biol. 11, 3419-3424.
21. Buss, J. E., Mumby, S. M., Casey, P. J., Oilman, A. G. and Sefton, B. M. (1987) Myristoylated α-subunits of guanine-nucleotide-binding regulatory proteins. Proc. natn. Acad. Sci. U.S.A. 84, 7493-7497.
22. Caron, M. G. and Lefkowitz, R. J. (1993) Catecholamine receptors: structure, function, and regulation. Recent Prog. Harm. Res. 48, 277-290.
23. Cazaubon, S., Parkar, P. J., Strosberg, A. D. and Couraud, P.-O. (1993) Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes. Biochem. J. 293, 381-386.
24. Clapham, D. (1993) Mutations in G-protein-linked receptors: novel insights, on disease. Cell 75, 1237-1239.
25. Clapham, D. E. and Neer, E. J. (1993) New roles for G protein β/γ dimers in transmembrane signalling. Nature 365, 403-406.
26. Coleman, D.E., Berghuis, A.M., Lee, L., Linder, M.E., Gilman, A.G. and Sprang, S.R. (1994a) Structures of active conformations of Gi alpha and the mechanism of GTP hydrolysis. Science 265, 1405-1412.
27. Coleman, D.E., Lee, L., Mixon, M.B., Berghuis, A.M., Gilman, A.G. and Sprang, S.R. (1994b) Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants in the GTP and GDP-bound states. J. Molec. Biol. 238, 630-634.
28. Collins, S., Bouvier, M., Bolanowski, M. A., Caron, M. G. and Lefkowitz, R. J. (1989) cAMP stimulates transcription of the β-adrenergic receptor gene in response to short-term agonist exposure. Proc. natn. Acad. Sci. U.S.A. 86, 4853-4857.
29. Collins, S., Caron, M. G. and Lefkowitz, R. J. (1988) Glucocorticoids regulation the transcription of the beta-2 adrenergic receptor gene. J. Biol. Chem. 263, 9067-9070.
30. Collins, S., Caron, M. G. and Lefkowitz, R. J. (1992) From ligand binding to gene expression:new insights into the regulation of G-protein-coupled receptors. Trends Biol. Sci. 17, 37-39.
31. Collins, S., Daniel, K. W., Rohlfs, E. M., Ramkumar, V., Taylor, I. L. and Gettys, T. W. (1994) Impaired expression and functional activity of the beta 3-and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Molec. Endocrinol. 8, 518-527.
32. Collins, S., Lohse, M. J., Caron, M. G. and Lefkowitz, R. J. (1991) Structure and regulation of G-protein-coupled receptors: the beta 2-adrenergic receptor as a model. Vitamins & Horm. 46, 1-39.
33. Coso, O. A., Chiariello, M., Kalinee, G., Kyriakis, J. M., Woodgett, J. and Gutkind, J. S. (1995) Transforming G-protein-coupled receptors potently activate JNK (SAPK). J. Biol. Chem. 270, 5620-5624.
34. 2-like protein implicated in the a-and α-factor response pathway. Cell 50, 1001-1010.
35. Dohlman, H. G., Thorner, J., Caron, M. G. and Lefkowitz, R. J. (1991) Model systems for the study of seven-transmembrane segment receptors. A. Rev. Biochem. 60, 653-688.
36. Feve, B., Elhadri, K., Quignard-Boulange, A. and Pairault, J. (1994) Transcriptional down-regulation by insulin of the beta 3-adrenergic receptor expression in 3T3-F442A adipocytes: a mechanism for repressing the cAMP signalling pathway. Proc. natn. Acad. Sci. U.S.A. 91, 5677-5681.
37. Fraser, C. M. (1995) Structure and functional analysis of G-protein-coupled receptors and potential diagnostic ligands. J. Nuclear Med. 36, 17-21.
38. Fredrik, L. M., Leeb-Lundberg, L. M. and Song, X.-H. (1991) Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells. J. Biol. Chem. 266, 7746-7749.
39. FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells. J. Biol. Chem. 269, 24328-24334.
40. George, S. T., Arbabian, M. A., Ruoho, A. E., Kiely, J. and Malbon, C. C. (1989) High-efficiency expression of mammalian β24-adrenergic receptors in baculovirus-infected insect cells. Biochem. Biophys. Res. Commun. 163, 1265-1269.
41. Gettys, T. W., Rohlfs, E. M., Prpic, V., Daniel, K. W., Taylor, I. L. and Collins, S. (1995) Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136, 20022-20032.
42. Gilman, A. G. (1987) G proteins: Transducers of receptor-generated signals. A. Rev. Biochem. 56, 615-649.
43. Graber, S. G., Figler, R. A., Kaiman-Maltese, V. K., Robishaw, J. D. and Garrison, J. C. (1992) Expression of functional G-protein beta-gamma dimers of defined subunit composition using a baculovirus expression system. J. Biol. Chem. 267, 13123-13126.
44. Granneman, J. G. and Lahners, K. N. (1994) Analysis of human and rodent beta 3-adrenergic receptor messenger ribonucleic acids. Endocrinology 135, 1025-1031.
45. Granneman, J. G. and Lahners, K. N. (1995) Regulation of mouse beta 3-adrenergic receptor gene expression and mRNA splice variants in adipocytes. Am. J. Physiol. 268, 1040-1044.
46. Guest, S. J., Hadcock, J. R., Watkins, D. C. and Malbon, C. C. (1990) β1-and β2-adrenergic receptor expression in differentiating 3T3-L1 cells: independent regulation at the level of mRNA. J. Biol. Chem. 265, 5370-5375.
47. Gusovsky, F., Lueders, J. E., Kohn, E. C. and Felder, C. C. (1993) Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ. J. Biol. Chem. 268, 7768-7772.
48. 4 subfamily of guanine nucleotide binding regulatory protein a subunits attenuate activation of phosphatidylinositol 4.5-biphosphate hydrolysis by hormones. J Biol. Chem. 266, 20519-20524.
49. Hadcock, J.R. and Malbon, C.C. (1988a) Regulation of β-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA. Proc. natn. Acad. Sci. U.S.A. 85, 8415-8419.
50. Hadcock, J.R. and Malbon, C.C. (1988b) Down-regulation of β-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc. natn. Acad. Sci. U.S.A. 85, 5021-5025.
51. Hadcock, J. R. and Malbon, C. C. (1991) Regulation of receptor expression by agonist: transcriptional and post-transcriptional controls. Trends Neurosci. 14, 242-247.
52. Hadcock, J. R. and Malbon, C. C. (1992) Adrenal dysfunction and G-protein-mediated pathways. In: G-proteins and Disease. pp. 109-127. Eds G. Milligan and M. Wakelam. Academic Press, London.
53. Hadcock, J. R. and Malbon, C. C. (1993) Agonist regulation of gene expression of adrenergic receptors, and G-proteins. J. Neurochem. 60, 1-9.
54. Hadcock, J. R., Port, J. D., Gelman, M. S. and Malbon, C. C. (1992) Cross-talk between tyrosine kinase and G-protein-linked receptors: phosphorylation of β2-adrenergic receptors in response to insulin. J. Biol. Chem. 267, 26017-26022.
55. Hadcock, J. R., Port, J. D. and Malbon, C. C. (1991) Cross-regulation between G-protein-mediated pathways: activation of the inhibitory pathway of adenylyl cyclase increases the expression of β2-adrenergic receptors. J. Biol. Chem. 266, 11915-11922.
56. Hadcock, J.R., Ros, M. and Malbon, C.C. (1989a) Agonist regulation of β-adrenergic receptor mRNA: analysis in S49 mouse lymphoma mutants. J. Biol. Chem. 264, 13956-13961.
57. iz2. J. Biol. Chem. 265, 14784-14790.
58. Hadcock, J.R., Wang, H.-Y. and Malbon, C.C. (1989b) Agonist-induced destabilization of β-adrenergic receptor mRNA. Attenuation of glucocorticoid-induced up-regulation of β-adrenergic receptors. J. Biol. Chem. 264, 19928-19934.
59. Hadcock, J.R., Williams, D.L. and Malbon, C.C. (1989c) Physiological regulation at the level of mRNA: analysis of the steady-state levels of specific mRNAs by DNA-excess solution hybridization. Am. J. Physiol. 256, 457-465.
60. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264, 12657-12665.
61. Hough, C. and Chuang, D. M. (1990) Agonist down-regulates β1-and β2-adrenergic receptor mRNA in C6 glioma cells. Biochem. Biophys. Res. Commun. 170, 46-52.
62. raf-1. J. Biol. Chem. 268, 20717-20720.
63. 1-adrenoceptors induces down-regulation of protein kinase C in vascular smooth muscle. J. Cardiocasc. Pharmacol. 20, 982-989.
64. 1MIF-2 cells. J. Biol. Chem. 268, 3610-3615.
65. r β-adrenergic receptor mRNA-binding (βARB) protein induced by agonists requires both an AUUUA pentamer and U-rich domains for RNA recognition. J. Biol. Chem. 268, 25769-25775.
66. Johnson, G. L. and Dhanasekaran, N. (1989) The G-protein family and their interaction with receptors. Endocr. Rev. 10, 317-331.
67. olfx. J. Biol. Chem. 265, 2671-2676.
68. Jong, Y.-J., Dalemar, L. R., Wilhelm, B. and Baenzieger, N. L. (1993) Human bradykinin B receptors isolated by receptor-specific monoclonal antibodies are tyrosine phosphorylated. Proc. natn. Acad. Sci. U.S.A. 90, 10994-10998.
69. Karoor, V., Baltensperger, K., Paul, H., Czech, M. P., Ruoho, A. and Malbon, C. C. (1995) Phosphorylation of tyrosyl residues 350/354 of the β-adrenergic receptor is obligatory for counterregulatory effects of insulin. J. Biol. Chem. 270, 25305-25308.
70. 1-adrenergic receptor expression by suppressing transcription of the receptor gene. Biochem. J. 302, 397-403.
71. 1b-adrenergic receptor by all amino acid substitutions at a single site. J. Biol. Chem. 267, 1430-1433.
72. Kong, G., Penn, R. and Benovic, J. L. (1994) A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. J. Biol. Chem. 269, 13084-13087.
73. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. and Wittig, B. (1992) Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 358, 424-426.
74. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. and Wittig, B. (1993) Selectivity in signal transduction determined by γ-subunits of heterotrimeric G proteins. Science 259, 832-843.
75. Kunapuli, P. and Benovic, J. L. (1993) Cloning and expression of GRK5: A member of the G-protein-coupled receptor kinase family. Proc. natn. Acad. Sci. U.S.A. 90, 5588-5592.
76. Lambright, D. G., Noel, J. P., Hamm, H. E. and Sigler, P. B. (1994) Structural determinants for activation of the alpha-subunit of a heterotrimeric G-protein. Nature 369, 621-627.
77. Lazar-Wesley, E., Hadcock, J. R., Malbon, C. C., Kunos, G. and Ishac, E. J. (1991) Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat. Endocrinology 129, 1116-1118.
78. Lefkowitz, R.J. (1993a) G-protein-coupled receptor kinases. Cell 74, 409-412.
79. Lefkowitz, R.J. (1993b) Turned on to ill effects. Nature 365, 603-605.
80. Linseman, D. A., Benjamin, C. W. and Jones, D. A. (1995) Convergence of Angiotensin II and platelet-derived growth factor receptor signalling cascades in vascular smooth muscle cells. J. Biol. Chem. 270, 12563-12568.
81. + channel in heart. Nature 325, 321-326.
82. Lyons, J., Landis, C. A., Harsh, G., Vallar, L., Grunewald, K., Feichtinger, H., Duh, Q. Y., Clark, O. H., Kawasaki, E., Bourne, H. R. and McCormick, F. (1990) Two G protein oncogenes in human endocrine tumors. Science 249, 655-659.
83. Mahan, L. C., McKernan, R. M. and Inselm, P. A. (1985) Genetic analysis of beta-adrenergic receptor internalization and downregulation. Proc. natn. Acad. Sci. U.S.A. 82, 129-133.
84. Malbon, C. C. (1980) Liver cell adenylate cyclase and β-adrenergic receptors: increased β-adrenergic receptor number and responsiveness in the hypothyroid rat. J. Biol. Chem. 255, 8692-8699.
85. 2-adrenergic receptor gene are obligate for glucocorticoid regulation of receptor in RNA levels. Biochem. Biophys. Res. Commun. 154, 676-681.
86. 2-subtypes in Receptor Purification, pp. 45-76. Ed. G. Litwack. Humana Press, Clifton, New Jersey.
87. Maltese, W. A. and Robishaw, J. D. (1990) Isoprenylation of C-terminal cysteine in a G-protein gamma subunit. J. Biol. Chem. 265, 18071-18074.
88. 1-adrenergic receptor mRNA levels. J. Biol. Chem. 266, 2233-2238.
89. iα2-specinc antisense RNA in vivo inhibits neonatal growth. Science 260, 991-995.
90. Negrescu, E. V., de Quintana, K. L. and Seiss, W. (1995) Platelet shape change induced by thrombin receptor activation. Rapid stimulation of tyrosine phosphorylation of novel protein substrates through an integrin-and Ca(2+)-independent mechanism. J. Biol. Chem. 270, 1057-1061.
91. Newton, A. C. and Williams, D. S. (1993) Rhodopsin is the major substrate of protein kinase C in the rod outer segments of photoreceptors. J. Biol. Chem. 268, 18181-18186.
92. Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334, 661-665.
93. Noel, J. P., Hamm, H. E. and Sigler, P. B. (1993) The 2.2 angstrom crystal structure of transducin a completed with GTPγS. Nature 366, 654-663.
94. Ohmichi, M., Sawada, T., Kanada, Y., Koike, K. and Hirota, K. (1994) Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. J. Biol. Chem. 269, 3783-3788.
95. Parola, A. L. and Kobilka, B. K. (1994) The peptide product of a 5′ leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. J. Biol. Chem. 269, 4497-4505.
96. Paxton, W. G., Marrero, M. B., Klein, J. D., Delafontaine, P., Berk, B. C. and Bernstein, K. E. (1994) The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases. Biochem. Biophys. Res. Commun. 200, 260-267.
97. Peng, Y. W., Robishaw, J. D., Levine, M. A. and Yau, K. W. (1992) Retinal rods and cones have distinct G-protein beta and gamma subunits. Proc. natn. Acad. Sci. U.S.A. 89, 10882-10886.
98. Ping, P. and Hammond, H. K. (1994) Diverse G-protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am. J. Physiol. 267, 2075-2085.
99. Pitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. J., Casey, P. J., Kim, C., Benovic, J. L., Kwatra, M. M., Caron, M. C. and Lefkowitz, R. J. (1992) Role of βγ subuniots of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257, 1264-1267.
100. 2-adrenergic receptor phosphorylation and increases β-adrenergic responsiveness. J. Biol. Chem. 267, 8468-8472.
101. Port, J.D., Huang, L.-Y. and Malbon, C.C. (1992b) P-Adrenergic agonists that down-regulate receptor mRNA up-regulate a 35,000-M, protein(s) that selectively binds to β-adrenergic receptor mRNAs. J. Biol. Chem. 267, 24103-24108.
102. Port, J. D. and Malbon, C. C. (1993) Integration of transmembrane signalling: crosstalk among G-protein-linked receptors and other signal transduction pathways. Trends Cardiovasc. Med. 3, 85-92.
103. Pouyssegur, J. and Seuwen, K. (1992) Transmembrane receptors and intracellular pathways that control proliferation. A. Rev. Physiol. 54, 195-210.
104. Prokipcka, R. D., Herrick, D. J. and Ross, J. (1994) Purification and properties of a protein that binds to the C-terminal coding region of the human c-myc mRNA. J. Biol. Chem. 269, 9261-9269.
105. Ptasznik, A., Traynor-Kaplan, A. and Bokoch, G. M. (1995) G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase. Shc adapter protein signaling complexes. J. Biol. Chem. 270, 19969-19973.
106. Rhee, S. G., Suh, P.-G., Ryu, S.-H. and Lee, S. Y. (1989) Studies of inositol phospholipid specific phospholipase C. Science 244, 546-550.
107. 1MF-2 smooth muscle cells. J. Clin. Invest. 88, 385-389.
108. Samama, P., Cotecchia, S., Costa, T. and Lefkowitz, R. J. (1993) A mutation-induced activation state of the β2-adrenergic receptor. J. Biol. Chem. 268, 4625-4636.
109. Savarese, T. M. and Fraser, C. M. (1992) In vitro mutagenesis and the search for structure-function relationships among G-protein-coupled receptors. Biochem. J. 283, 101-118.
110. Schiavi, S. C., Belasco, J. G. and Greenberg, M. E. (1992) Regulation of proto-oncogene mRNA stability. Biochim. Biophys. Acta 1114, 95-106.
111. Shih, W. and Malbon, C. C. (1994) Oligodeoxynucleotides antisense to protein kinase-A, -Q and βARK reveal novel cell type-specific roles in agonist-induced desensitization. Proc. natn. Acad. Sci. U.S.A. 91, 12193-12197.
112. Shilo, L., Sakaue, M., Thomas, J. M., Philip, M. and Hoffman, B. B. (1994) Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP. Cell. Signall. 6, 73-82.
113. Sibley, D. R., Strasser, R. H., Benovic, J. L., Daniel, K. and Lefkowitz, R. J. (1986) Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its coupling to adenylate cyclase and subcellular distribution. Proc. natn. Acad. Sci. U.S.A. 83, 9408-9412.
114. Simon, M. I., Strathmann, M. P. and Gautam, N. (1991) Diversity of G proteins in signal transduction. Science 252, 802-808.
115. Simonson, M. S. and Herman, W. H. (1993) Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signalling by endothelin-1. J. Biol. Chem. 268, 9347-9357.
116. Stadel, J. M., Nambi, P., Shorr, R. G. L., Sawyer, D. R., Caron, M. G. and Lefkowitz, R. J. (1983) Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the β-adrenergic receptor. Proc. natn. Acad. Sci. U.S.A. 80, 3173-3177.
117. Sternweiss, P. C. and Robishaw, J. D. (1984) Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J. Biol. Chem. 259, 13806-13811.
118. 1, epithelial cells. J. Cell Biol. 114, 1113-1124.
119. iα2 attenuates inhibitory adenylylcyclase in neuroblastoma/glioma hybrid (NG-108-15) cells. J. Biol. Chem. 269, 14307-14313.
120. Tang, W. J. and Gilman, A. G. (1991) Type-specific regulation of adenylyl cyclase by G protein β/γ subunits. Science 254, 1500-1503.
121. iα. Science 261, 218-221.
122. Tholanikunnel, B. G., Granneman, J. and Malbon, C. C. (1995) The 35.000-M, β-adrenergic receptor mRNA-binding (βARB) protein differentiates among subtype mRNAs. J. Biol. Chem. 270, 12787-12793.
123. Vivat, V., Cohen-Tannoudji, J., Revelli, J. P., Muzzin, P., Giacobino, J. P., Maltier, J. P. and Legrand, C. (1992) Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium. J. Biol. Chem. 267, 7975-7978.
124. 13α stimulates Na-H exchange. J. Biol. Chem. 269, 4712-4714.
125. Voyno-Yasenetskaya, T.A., Pace, A.M. and Bourne, H.R. (1994b) Mutant α-subunits of G12 and G13 proteins induce neoplastic transformation in Rat-1 fibroblasts. Oncogene 9, 2559-2565.
126. Vu, T. K. H., Hung, D. T., Wheaton, V. I. and Coughlin, S. R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068.
127. Wang, H.-y., Watkins, D. C. and Malbon, C. C. (1992) Antisense Oligodeoxynucleotides to G, protein α-subunit sequence accelerate differentiation of fibroblasts to adipocytes. Nature 358, 334-337.
128. iα2. Science 258, 1373-1375.
129. Weiner, N. (1980) Drugs that inhibit adrenergic nerves and block adrenergic receptors. In: The Pharmacological Basis of Therapy (6th Edn), pp. 176-210. Eds A. G. Gilman, L. S. Goodman, and A. Gilman. Macmillan Publishing Company, New York.
130. Wilusz, J. and Shenk, T. (1988) A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif. Cell 52, 221-228.
131. 1-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. J. Biol. Chem. 268, 19196-19199.
132. i, substrates. Nature 336, 680-682.
133. Zachary, I., Gil, J., Lehman, W., Sinnett-Smith, J. and Rozengurt, E. (1991) Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells. Proc natn. Acad. Sci. U.S.A. 88, 4577-4581.
134. Zhang, W. and Brewer, G. (1993) Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF-1. Molec. cell. Biol. 13, 7652-7655.