Peb1p (Pas7p) is an intraperoxisomal receptor for the NH2-terminal, type 2, peroxisomal targeting sequence of thiolase: Peb1p itself is targeted to peroxisomes by an NH2-terminal peptide

Journal of Cell Biology

Volumn 132, Issue 3, 1996, Pages 325-334

  Zhang, Jing Wei ^a   Lazarow, Paul B ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; DIGITONIN; EPITOPE; HEMAGGLUTININ; HYBRID PROTEIN; MEMBRANE RECEPTOR; OLIGOPEPTIDE; RECEPTOR PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; YEAST;

ACETYL-COA C-ACETYLTRANSFERASE; AMINO ACID SEQUENCE; BINDING SITES; FUNGAL PROTEINS; GENOTYPE; INTRACELLULAR MEMBRANES; KINETICS; MEMBRANE PROTEINS; MICROBODIES; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PLASMIDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0030071815     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.132.3.325     Document Type: Article

References (51)

1. Bartel, P., C T. Chien, R. Sternglanz, and S Fields. 1993. Elimination of false positives that arise in using the two-hybrid system. Biotechniques. 14:920-924.
2. Baudhuin, P., H Beaufay, Y. Rahman-Li, O. Z Sellinger, R. Wattiaux, P. Jacques, and C. de Duve 1964. Tissue fractionation studies. 17 Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue. Biochem J. 92:179-184.
3. Bergmeyer, H. U., M. Graßl, and H.-E. Walter. 1983. Samples, reagents, assessment of results In Methods of Enzymatic Analysis. Volume II. 3rd edition. H. U. Bergmeyer, J. Bergmeyer, and M. Graßl, editors. Verlag Chemie, Weiheim. 211-213.
4. Blattner, J., H. Dörsam, and C. E. Clayton. 1995. Function of N-terminal import signals in trypanosome microbodies. FEBS (Fed Eur. Biochem. Soc.) Lett. 360:310-314.
5. Brocard, C., F. Kragler, M. M. Simon, T. Schuster, and A. Hartig. 1994. The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. Biochem. Biophys. Res. Commun. 204:1016-1022.
6. Chevray, P. M., and D. Nathans. 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci USA. 89:5789-5793.
7. de Duve, C. 1967. General principles. In Enzyme Cytology. D. B. Roodyn, editor. Academic Press, New York. 1-26
8. Dodt, G., N. Braverman, C. Wong, A. Moser, H. W. Moser, P. Watkins, D. Valle, and S. J. Gould. 1995. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nature Genet 9:115-125.
9. Erdmann, R. 1994. The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae Yeast 10:935-944.
10. Erdmann, R., and W.-H. Kunau. 1994. Purification and immunolocalization of the peroxisomal 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast. 10:1173-1182.
11. Faber, K. N., I. Keizer-Gunnink, D. Pluim, W. Harder, G. AB, and M. Veenhuis. 1995. The N-terminus of amine oxidase of Hansenula polymorpha contains a peroxisomal targeting signal. FEBS (Fed. Eur. Biochem Soc.) Lett. 357:115-120.
12. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature (Lond.). 340:245-246.
13. Fransen, M , C. Brees, E. Baumgart, J C. T. Vanhooren, M. Baes, G. P. Mannaerts, and P. P. Van Veldhoven. 1995. Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor. J. Biol. Chem. 270:7731-7736.
14. Gietl, C. 1990. Glyoxysomal malate dehydrogenase from watermelon is synthesized with an amino-terminal transit peptide. Proc. Natl. Acad. Sci. USA 87:5773-5777.
15. Glover, J. R., D. W. Andrews, and R. A. Rachubinski. 1994. Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc. Natl Acad. Sci. USA 91:10541-10545.
16. Glover, J. R., D. W. Andrews, S. Subramani, and R. A. Rachubinski. 1994. Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo. J. Biol. Chem. 269:7558-7563.
17. Gould, S. J , G.-A. Keller, N. Hosken, J. Wilkinson, and S. Subramani. 1989. A conserved tripeptide sorts proteins to peroxisomes. J. Cell Biol. 108:1657-1664.
18. Gould, S. J., S. Krisans, G.-A. Keller, and S. Subramani. 1990. Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins. J. Cell Biol. 110:27-34.
19. Hill, J. E., A. M. Myers, T. J. Koerner, and A. Tzagoloff. 1986. Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast. 2:163-167
20. Igual, J. C., E. Matallana, C. Gonzalez-Bosch, L. Franco, and J. E. Perez-Ortin. 1991. A new glucose-repressible gene identified from the analysis of chromatin structure in deletion mutants of yeast SUC2 locus. Yeast 7: 379-389.
21. Kamiryo, T., Y. Sakasegawa, and H. Tan. 1989. Expression and transport of Candida tropicalis peroxisomal acyl-CoA oxidase in the yeast Candida maltosa. Agric Biol Chem. 53:179-186.
22. Kang, P. J., J. Ostermann, J. Shilling, W. Neupert, E. A. Craig, and N. Pfanner. 1990. Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (Lond.). 348:137-143.
23. Keller, G.-A., S. Krisans, S. J. Gould, J. M. Sommer, C C. Wang, W. Schliebs, W -H. Kunau, S. Brody, and S. Subramani. 1991. Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes and glycosomes. J Cell Biol. 114:893-904.
24. Kragler, F., A Langeder, J. Raupachova, M Binder, and A. Hartig. 1993. Two independent peroxisomal targeting signals in catalase A of Saccharomyces cerevisiae. J. Cell Biol. 120:665-673.
25. Kunau, W.-H., A. Beyer, T. Franken, K. Götte, M. Marzioch, J. Saidowsky, A. Skaletz-Rorowski, and F. F. Wiebel. 1993. Two complementary approaches to study peroxisome biogenesis in Saccharomyces cerevisiae: forward and reversed genetics Biochimie. 75:209-224.
26. Lazarow, P. B. 1993. Genetic approaches to studying peroxisome biogenesis. Trends Cell Biol 3:89-93.
27. Lazarow, P. B., R Thieringer, G. Cohen, T. Imanaka, and G. M Small. 1991. Protein import into peroxisomes in vitro In Methods in Cell Biology. Vol 34 A Tartakoff, editor. Academic Press, San Diego, CA. 304-326.
28. Marzioch, M., R. Erdmann, M Veenhuis, and W.-H. Kunau 1994. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes, EMBO J. 13:4908-4917.
29. McCollum, D., E. Monosov, and S. Subramani. 1993. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells - The PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family. J. Cell Biol 121:761-774.
30. Motley, A., E. Hettema, B. Distel, and H Tabak. 1994. Differential protein import deficiencies in human peroxisome assembly disorders. J. Cell Biol. 125:755-767.
31. Neer, E. J., C. J. Schmidt, R. Nambudripad, and T. F. Smith. 1994 The ancient regulatory-protein family of WD-repeat proteins. Nature (Lond.). 371 (22):297-300.
32. Osumi, T., T. Tsukamoto, S. Hata, S. Yokota, S. Miura, Y. Fujiki, M. Hijikata, S. Miyazawa, and T. Hashimoto. 1991. Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting. Biochem. Biophys. Res. Commun. 181:947-954.
33. Poole, B., F. Leighton, and C. de Duve. 1969. The synthesis and turnover of rat liver peroxisomes II. Turnover of peroxisome proteins. J. Cell Biol. 41:536-546.
34. Purdue, P. E., and P. B. Lazarow. 1994. Peroxisome biogenesis: multiple pathways of protein import. J. Biol. Chem. 269:30065-30068.
35. Purdue, P. E., and P. B. Lazarow. 1995. Identification of peroxisomal membrane ghosts with an epitope-tagged integral membrane protein in yeast mutants lacking peroxisomes. Yeast. 11:1045-1060.
36. Rothstein, R. 1983. One step gene disruption in yeast. Methods Enzymol. 101:202-213.
37. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
38. Schiestl, R. H., and R. D. Gietz. 1989. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr. Genet. 16:339-346.
39. Sherman, F., G. R. Fink, and J B. Hicks. 1986. Methods in yeast genetics Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 1-186.
40. Shimozawa, N., T. Tsukamoto, Y. Suzuki, T. Orii, Y. Shirayoshi, T. Mori, and Y. Fujiki. 1992. A human gene responsible for Zellweger syndrome that affects peroxisome assembly. Science (Wash. DC). 255:1132-1134.
41. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics. 122:19-27.
42. Small, G. M., L. J. Szabo, and P. B Lazarow. 1988. Acyl-CoA oxidase contains two targeting sequences each of which can mediate protein import into peroxisomes. EMBO J. 7:1167-1173.
43. Subramani, S. 1993. Protein import into peroxisomes and biogenesis of the organelle. Annu. Rev. Cell Biol. 9:445-478.
44. Swinkels, B. W., S. J. Gould, A. G. Bodnar, R. A. Rachubinski, and S. Subramani. 1991. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J. 10:3255-3262
45. Thieringer, R., H. Shio, Y. Han, G. Cohen, and P. B. Lazarow. 1991. Peroxisomes in Saccharomyces cerevisiae: immunofluorescence analysis and import of catalase A into isolated peroxisomes. Mol. Cell Biol. 11:510-522.
46. Van Der Leij, I., M. M. Franse, Y. Elgersma, B. Distel, and H. F. Tabak. 1993. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 90:11782-11786
47. Waterham, H. R., V. I. Titorenko, P. Haima, J. M. Cregg, W. Harder, and M Veenhuis 1994. The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals. J. Cell Biol. 127: 737-749.
48. Wiemer, E. A., W. M. Nuttley, B. L. Bertolaet, X. Li, U. Francke, M. J Wheelock, U. K. Anne, K. R. Johnson, and S. Subramani. 1995. Human peioxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J. Cell Biol 130:51-65.
49. Zhang, J. W., Y. Han, and P. B. Lazarow. 1993. Peroxisome clustering mutants and peroxisome biogenesis mutants of Saccharomyces cerevisiae J Cell Biol. 123:1133-1147.
50. Zhang, J. W., and P. B Lazarow. 1994. PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intraperoxisomal protein which is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J. Cell Biol 129:65-80.
51. Zhang, J W., C. Luckey, and P. B. Lazarow. 1993. Three peroxisome protein packaging pathways suggested by selective permeabilization of yeast mutants defective in peroxisome biogenesis. Mol. Biol. Cell. 4:1351-1359.