Human immunodeficiency virus type 1 vpu protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization

Virology

Volumn 279, Issue 1, 2001, Pages 201-209

  González, María Eugenia ^a   Carrasco, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

6K; Accessory protein; Alphavirus vector; Gene expression; Glycoprotein processing; HIV 1; Membrane permeability; Membrane proteins; Sindbis virus; Viral pathogenesis; Vpu

Indexed keywords

6K PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS VECTOR; VPU PROTEIN;

ALPHA VIRUS; ANIMAL CELL; ARTICLE; BUDDING; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TRANSPORT; SINDBIS VIRUS; VIRION; VIRUS PARTICLE; VIRUS PATHOGENESIS;

ALPHAVIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SINDBIS VIRUS;

EID: 0035915994     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0708     Document Type: Article

References (39)

1. Modification of membrane permeability by animal viruses
2. Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: The cytoplasmic domain of CD4 contributes to Vpu sensitivity
3. Effects of Vpu expression on Xenopus oocyte membrane conductance
4. Identification of a protein encoded by the vpu gene of HIV-1
5. Maturation and assembly of retroviral glycoproteins
6. The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels
7. Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein
8. Site-directed mutations in the Sindbis virus 6K protein reveal sites for fatty acylation and the underacylated protein affects virus release and virion structure
9. The Sindbis virus 6K protein can be detected in virions and is acylated with fatty acids
10. The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability
11. Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses
12. Molecular cloning and characterization of the HTLV-III virus associated with AIDS
13. Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation
14. Human immunodeficiency virus type 1 Vpu modifies viral cytopathic effect through augmented virus release
15. The human immunodeficiency virus type 1 (HIV-1) vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules
16. Intracellular membrane traffic of human immunodeficiency virus type 1 envelope glycoproteins: Vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum
17. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release
18. Vpu-induced degradation of CD4: Requirement for specific amino acid residues in the cytoplasmic domain of CD4
19. In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: The small 6.000-molecular-weight membrane protein modulates virus release
20. Human immunodeficiency virus type 1 Vpu protein is an oligomeric type 1 integral membrane protein
21. Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1
22. Simulation of the HIV-1 Vpu transmembrane domain as a pentameric bundle
23. Modification of membrane permeability during Semliki Forest virus infection
24. Mutational analysis of the human immunodeficiency virus type 1 Vpu transmembrane domain that promotes the enhanced release of virus-like particles from the plasma membrane of mammalian cells
25. Expression of HIV-1 envelope glycoproteins by Semliki Forest virus vectors
26. The human immunodeficiency virus type 1 Vpu protein tethered to the CD4 extracellular domain is localized to the plasma membrane and is biologically active in the secretory pathway of mammalian cells: Implications for the mechanisms of Vpu function
27. The ion channel activity of the influenza virus M2 protein affects transport though the Golgi apparatus
28. Semliki Forest virus 6K protein modifies membrane permeability after inducible expression in Escherichia coli cells
29. An in-frame insertion into the Sindbis virus 6K gene leads to defective proteolytic processing of the virus glycoproteins, a trans-dominant negative inhibition of normal virus formation, and interference in virus shut off of host-cell protein synthesis
30. Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells
31. Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II
32. The alphaviruses: Gene expression, replication, and evolution
33. A novel gene of HIV-1, vpu, and its 16-kilodalton product
34. The human immunodeficiency virus type 1 Vpu protein: A potential regulator of proteolysis and protein transport in the mammalian secretory pathway
35. Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution
36. Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes
37. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
38. Interactions between PE2, E1, and 6K required for assembly of alphaviruses studied with chimeric viruses