Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat

Molecular Brain Research

Volumn 94, Issue 1-2, 2001, Pages 166-177

  Deransart, Colin ^a   Landwehrmeyer, G Bernhard ^b   Feuerstein, Thomas J ^a   Lücking, Carl H ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Absence epilepsy; Basal ganglia; Dopamine; Genetic model; In situ hybridization

Indexed keywords

BIOLOGICAL MARKER; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC SYSTEM; EPILEPSY; GENETIC MODEL; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; NERVE CELL; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; STRAIN DIFFERENCE; TISSUE DISTRIBUTION;

ANIMALS; DISEASE MODELS, ANIMAL; DOPAMINE; EPILEPSY, ABSENCE; GENE EXPRESSION; IN SITU HYBRIDIZATION; NEURONS; NUCLEUS ACCUMBENS; RATS; RATS, INBRED STRAINS; RATS, MUTANT STRAINS; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D5; RNA, MESSENGER; UP-REGULATION;

EID: 0035914197     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00240-6     Document Type: Article

References (59)

1. Amygdala kindling and anxiety in the rat
2. D-2 agonists protect rodents against pilocarpine-induced convulsions by stimulating D-2 receptors in the striatum, but not in the substantia nigra
3. Anticonvulsant effect of striatal dopamine D2 receptor stimulation: Dependence on cortical circuits?
4. Co-expression of dopamine transporter mRNA and tyrosine hydroxylase mRNA in ventral mesencephalic neurones
5. Antiepileptic drugs - Their effects on kindled seizures and kindling-induced learning impairments
6. Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa
7. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: Comparison with D2 receptor mRNA
8. Cloning and expression of a rat D2 dopamine receptor cDNA
9. Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker
10. Identification and localization of dopamine receptor subtypes in rat olfactory mucosa and bulb: A combined in situ hybridization and ligand binding radioautographic approach
11. Mesolimbic dopamine receptor increases 2 weeks following hippocampal kindling
12. Pathophysiological mechanisms of genetic absence epilepsy in the rat
13. Enhancement of basal and pentylenetetrazol (PTZ)-stimulated dopamine release in the brain of freely moving rats by PTZ-induced kindling
14. Dopamine characteristics in different rat genotypes: The relation to absence epilepsy
15. The role of basal ganglia in the control of generalized absence seizures
16. Dopamine in the striatum modulates seizures in a genetic model of absence epilepsy in the rat
17. Phenotypical characterization of neurons expressing the dopamine D3 receptor
18. Mechanisms of seizure control mediated by gamma aminobutyric acid: Role of the substantia nigra
19. Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling
20. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
21. The putative dopamine D3 agonist, 7-OH-DPAT, reduces dopamine release in the nucleus accumbens and electrical self-stimulation to the ventral tegmentum
22. Complete coding sequence of rat tyrosine hydroxylase mRNA
23. The mnemonic effects of kindling
24. Amygdala kindling in the rat: Anxiogenic-like consequences
25. Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy
26. Simultaneous isotopic and nonisotopic in situ hybridization histochemistry with cRNA probes
27. Cloning and expression of a cocaine-sensitive rat dopamine transporter
28. Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities
29. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments
30. Differential visualization of dopamine D2 and D3 receptor sites in rat brain. A comparative study using in situ hybridization histochemistry and ligand binding autoradiography
31. A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons
32. Short- and long-term alterations of gene expression in limbic structures by repeated electroconvulsive-induced seizures
33. Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states
34. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
35. Cell-type-specific expression of catecholamine transporters in the rat brain
36. Distribution of D5 dopamine receptor mRNA in rat brain
37. Activation of the retrohippocampal region in the rat causes dopamine release in the nucleus accumbens: Disruption by fornix section
38. Multiple D2 dopamine receptors produced by alternative RNA splicing
39. Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation
40. Dopamine D3 receptor antisense influences dopamine synthesis in rat brain
41. The rat dopamine D4 receptor: Sequence, gene structure, and demonstration of expression in the cardiovascular system
42. Opposite changes of dopamine turnover in prefrontal cortex and nucleus accumbens after amygdaloid kindling
43. Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and susceptibility to idiopathic generalized epilepsy
44. The D3 dopamine receptor in cellular and organismal function
45. Molecular biology of dopamine receptors
46. Electroconvulsive shock increases dopamine D1 and D2 receptor mRNA in the nucleus accumbens of the rat
47. NMDA receptor-mediated pilocarpine-induced seizures: Characterization in freely moving rats by microdialysis
48. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
49. Function and therapeutic potential of the dopamine D3 receptor
50. Ontogeny of dopamine D3 receptors in the nucleus accumbens of the rat
51. The role of dopamine in epilepsy
52. Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): Transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin
53. Effect of pentylenetetrazol on the expression of tyrosine hydroxylase mRNA and norepinephrine and dopamine transporter mRNA
54. Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: Differential expression pattern in rat brain compared with the D1A receptor
55. Dopamine-sensitive anticonvulsant site in the rat striatum
56. Ontogeny of spontaneous petit mal-like seizures in Wistar rats
57. Anticonvulsant effects of ipsilateral but not controlateral microinjections of the dopamine D2 agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats
58. Effect of drugs affecting dopaminergic neurotransmission in rats with spontaneous petit mal-like seizures