Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 497, Issue 1-2, 2001, Pages 223-233

  Hatanaka, Naoya ^a   Yamazaki, Hiroshi ^a   Oda, Yoshimitsu ^b   Guengerich, F Peter ^c   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1 Aminopyrene; 1 Nitropyrene; Acetyltransferase; Human P450 1B1; S. typhimurium NM2009; The umu gene expression

Indexed keywords

1 AMINOPYRENE; 1 NITRO 3 PYRENOL; 1 NITRO 6 PYRENOL; 1 NITRO 8 PYRENOL; 1 NITROPYRENE; 4,5 DIHYDROXY 4,5 DIOL 1 NITROPYRENE; ACYLTRANSFERASE; ALCOHOL DERIVATIVE; CYTOCHROME P450 1B1; ION; NITRENIUM ION; NITROREDUCTASE; O ACYLTRANSFERASE; PYRENE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ACETYLATION; AEROBIC METABOLISM; ARTICLE; CARCINOGENICITY; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; EPOXIDATION; ESCHERICHIA COLI; GENE EXPRESSION; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; SALMONELLA TYPHIMURIUM; SOS CHROMOTEST; STRAIN DIFFERENCE;

ACETYLTRANSFERASES; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; HUMANS; MICROSOMES, LIVER; MUTAGENS; NADPH-FERRIHEMOPROTEIN REDUCTASE; PYRENES; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SOS RESPONSE (GENETICS);

EID: 0035909486     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00254-6     Document Type: Article

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