HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program

Journal of Cell Biology

Volumn 154, Issue 6, 2001, Pages 1161-1171

  Gao, Xiangming ^a   Chandra, Tanya ^a   Gratton, Michel Olivier ^b   Quélo, Isabelle ^a   Prud'homme, Josée ^a   Stifani, Stefano ^b   St Arnaud, René ^a,c  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

bHLH; Differentiation; HES1; HES6; MyoR

Indexed keywords

HYBRID PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES6; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA BINDING; MOUSE; MUSCLE DEVELOPMENT; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MOTIF; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE; HOMEODOMAIN PROTEINS; HUMANS; MICE; MUSCLE DEVELOPMENT; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; NUCLEAR PROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES; YEASTS;

MAMMALIA;

EID: 0035904241     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200104058     Document Type: Article

References (53)

1. Twist and Notch negatively regulate adult muscle differentiation in Drosophila
2. Notch signaling
3. Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro
4. The bHLH gene Hes6, an inhibitor of Has1, promotes neuronal differentiation
5. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
6. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
7. Functional antagonism between c-Jun and MyoD proteins: A direct physical association
8. Plasticity of the differentiated state
9. Groucho/TLE family proteins and transcriptional repression
10. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif
11. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development
12. Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: Implications for evolutionary conservation of transcription repression mechanisms
13. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
14. M-twist is an inhibitor of muscle differentiation
15. Delta-1 activation of notch-1 signaling results in HES-1 transactivation
16. Overexpression of Id protein inhibits the muscle differentiation program: In vivo association of Id with E2A proteins
17. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
18. Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation
19. Tetratrico peptide repeat interactions: To TPR or not to TPR?
20. Mist1: A novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern
21. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD
22. Jagged: A mammalian ligand that activates Notch 1
23. Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning
24. Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element
25. MyoR: A muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD
26. Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
27. The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfal
28. pEF-BOS, a powerful mammalian expression vector
29. Defining the regulatory networks for muscle development
30. Myogenin gene disruption results in perinatal lethality because of severe muscle defect
31. HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
32. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
33. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
34. Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues
35. Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development
36. A new transcriptional-activation motif restricted to a class of helix-loop- helix proteins is functionally conserved in both yeast and mammalian cells
37. Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice
38. MyoD or Myf-5 is required for the formation of skeletal muscle
39. Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila
40. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
41. The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription
42. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
43. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist
44. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jk/Su(H)
45. Enhancer of split-D. A dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein
46. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
47. Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors
48. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta
49. Muscle-specific transcriptional activation by MyoD
50. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C
51. Rapid identification of key amino-acid-DNA contacts through combinatorial peptide synthesis
52. Skeletal muscle determination and differentiation: Story of a core regulatory network and its context